Coronary heart disease (CHD) is a common heart disease and the leading cause of
cardiovascular death. Apoptosis and autophagy are two forms of programmed cell deaths …

Stroke is the second leading cause of death, after ischemic heart disease, and accounts for
9% of deaths worldwide. According to the World Health Organization [WHO], 15 million …

Viral infections are dangerous diseases for human health worldwide, which lead to
significant morbidity and mortality each year. Because of their importance and the lack of …

In advanced atherosclerosis, macrophage apoptosis coupled with defective phagocytic
clearance of the apoptotic cells (efferocytosis) promotes plaque necrosis, which precipitates …

The progressive loss of cardiomyocytes caused by cell death leads to cardiac dysfunction
and heart failure (HF). Rapamycin has been shown to be cardioprotective in pressure …

Doxorubicin (DOX) is one of the most widely used and successful antitumor drugs, but its
cumulative and dose-dependent cardiac toxicity has been a major concern of oncologists in …

Abstract Ischemia/reperfusion (I/R) of the heart leads to increased autophagic flux.
Preconditioning stimulates autophagic flux by AMPK and PI3-kinase activation and mTOR …

Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli
that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents …

Aims The present study was designed to examine the mechanism involved in mitochondrial
aldehyde dehydrogenase (ALDH2)-induced cardioprotection against ischaemia/reperfusion …

The endoplasmic reticulum (ER) is a multifunctional intracellular organelle supporting many
processes required by virtually every mammalian cell, including cardiomyocytes. It performs …