Learning without neurons in physical systems

M Stern, A Murugan - Annual Review of Condensed Matter …, 2023 - annualreviews.org
Learning is traditionally studied in biological or computational systems. The power of
learning frameworks in solving hard inverse problems provides an appealing case for the …

Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics

BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …

The intertwined physics of active chemical reactions and phase separation

D Zwicker - Current Opinion in Colloid & Interface Science, 2022 - Elsevier
Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …

Dynamical control enables the formation of demixed biomolecular condensates

AZ Lin, KM Ruff, F Dar, A Jalihal, MR King… - Nature …, 2023 - nature.com
Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …

Theory and simulation of multiphase coexistence in biomolecular mixtures

WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …

A model for organization and regulation of nuclear condensates by gene activity

HH Schede, P Natarajan, AK Chakraborty… - Nature …, 2023 - nature.com
Condensation by phase separation has recently emerged as a mechanism underlying many
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …

Phase-separated droplets swim to their dissolution

E Jambon-Puillet, A Testa, C Lorenz, RW Style… - Nature …, 2024 - nature.com
Biological macromolecules can condense into liquid domains. In cells, these condensates
form membraneless organelles that can organize chemical reactions. However, little is …

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

AR Tejedor, I Sanchez-Burgos… - Nature …, 2022 - nature.com
Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …

Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

AR Tejedor, R Collepardo-Guevara… - The Journal of …, 2023 - ACS Publications
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …

Evolved interactions stabilize many coexisting phases in multicomponent liquids

D Zwicker, L Laan - Proceedings of the National Academy of Sciences, 2022 - pnas.org
Phase separation has emerged as an essential concept for the spatial organization inside
biological cells. However, despite the clear relevance to virtually all physiological functions …