Learning without neurons in physical systems
Learning is traditionally studied in biological or computational systems. The power of
learning frameworks in solving hard inverse problems provides an appealing case for the …
learning frameworks in solving hard inverse problems provides an appealing case for the …
Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
BA Conti, M Oppikofer - Trends in Pharmacological Sciences, 2022 - cell.com
Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …
The intertwined physics of active chemical reactions and phase separation
D Zwicker - Current Opinion in Colloid & Interface Science, 2022 - Elsevier
Phase separation is the thermodynamic process that explains how droplets form in
multicomponent fluids. These droplets can provide controlled compartments to localize …
multicomponent fluids. These droplets can provide controlled compartments to localize …
Dynamical control enables the formation of demixed biomolecular condensates
Cellular matter can be organized into compositionally distinct biomolecular condensates.
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates …
Theory and simulation of multiphase coexistence in biomolecular mixtures
WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …
living cells. Although many condensates are believed to form as a result of phase …
A model for organization and regulation of nuclear condensates by gene activity
Condensation by phase separation has recently emerged as a mechanism underlying many
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …
nuclear compartments essential for cellular functions. Nuclear condensates enrich nucleic …
Phase-separated droplets swim to their dissolution
Biological macromolecules can condense into liquid domains. In cells, these condensates
form membraneless organelles that can organize chemical reactions. However, little is …
form membraneless organelles that can organize chemical reactions. However, little is …
Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it
Biomolecular condensates, some of which are liquid-like during health, can age over time
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …
becoming gel-like pathological systems. One potential source of loss of liquid-like properties …
Time-dependent material properties of aging biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations
Biomolecular condensates are important contributors to the internal organization of the cell
material. While initially described as liquid-like droplets, the term biomolecular condensates …
material. While initially described as liquid-like droplets, the term biomolecular condensates …
Evolved interactions stabilize many coexisting phases in multicomponent liquids
Phase separation has emerged as an essential concept for the spatial organization inside
biological cells. However, despite the clear relevance to virtually all physiological functions …
biological cells. However, despite the clear relevance to virtually all physiological functions …