Memory B cells (MBCs) are critical for the rapid development of protective immunity
following re-infection. MBCs capable of neutralizing distinct subclasses of pathogens, such …

Clinical evidence strongly suggests that certain live vaccines, in particular bacille Calmette–
Guérin (BCG) and measles vaccines, can reduce all-cause mortality, most probably through …

Antibodies produced by antibody-secreting plasma cells (ASCs) underlie multiple forms of
long-lasting immunity. Here we examined the mechanisms regulating ASC turnover and …

Memory B cells can be produced from the classical germinal center (GC) pathway or a less
understood GC-independent route. We used antigen-based cell enrichment to assess the …

Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon
antigen recall. How this decision is programmed is not understood. We found that the …

Effective vaccines induce high-affinity memory B cells and durable antibody responses
through accelerated mechanisms of natural selection. Secondary changes in antibody …

In response to T cell-dependent antigens, B cells proliferate extensively to form germinal
centres (GC), and then differentiate into memory B (Bmem) cells or long-lived plasma cells …

Humoral immunity following vaccination or infection is mainly derived from two types of cells:
memory B cells and plasma cells. Memory B cells do not actively secrete antibody but …

Humoral immunity consists of pre-existing antibodies expressed by long-lived plasma cells
and rapidly reactive memory B cells (MBC). Recent studies of MBC development and …

The local environment may affect the development and function of tissue-resident T
regulatory cells (Tregs), which are crucial for controlling inflammation. Although the aryl …