Biophysical computational models are complementary to experiments and theories,
providing powerful tools for the study of neurological diseases. The focus of this review is the …

Movement disorders arise from the complex interplay of multiple changes to neural circuits.
Successful treatments for these disorders could interact with these complex changes in …

In Parkinson's disease, an increase in beta oscillations within the basal ganglia nuclei has
been shown to be associated with difficulty in movement initiation. An important role in the …

Movement disorders in Parkinson's disease (PD) are commonly associated with slow
oscillations and increased synchrony of neuronal activity in the basal ganglia. The neural …

Parkinsonism leads to various electrophysiological changes in the basal ganglia-
thalamocortical system (BGTCS), often including elevated discharge rates of the …

In this paper, we present a novel Bayesian adaptive dual controller (ADC) for autonomously
programming deep brain stimulation devices. We evaluated the Bayesian ADC's …

Whilst exaggerated bursts of beta frequency band oscillatory synchronization in the
subthalamic nucleus have been associated with motor impairment in Parkinson's disease, a …

Absence epilepsy is believed to be associated with the abnormal interactions between the
cerebral cortex and thalamus. Besides the direct coupling, anatomical evidence indicates …

We present a technical development in the dynamic causal modelling of
electrophysiological responses that combines qualitatively different neural mass models …

A key pathology in the development of Parkinson's disease is the occurrence of persistent
beta oscillations, which are correlated with difficulty in movement initiation. We investigated …