[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018‏ - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

Deafness: from genetic architecture to gene therapy

C Petit, C Bonnet, S Safieddine - Nature Reviews Genetics, 2023‏ - nature.com
Progress in deciphering the genetic architecture of human sensorineural hearing
impairment (SNHI) or loss, and multidisciplinary studies of mouse models, have led to the …

MicroRNAs: history, biogenesis, and their evolving role in animal development and disease

M Bhaskaran, M Mohan - Veterinary pathology, 2014‏ - journals.sagepub.com
The discovery of microRNAs (miRNAs) in 1993 followed by developments and discoveries
in small RNA biology have redefined the biological landscape by significantly altering the …

MicroRNAs in stress signaling and human disease

JT Mendell, EN Olson - Cell, 2012‏ - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

MicroRNAs in human cancer

TA Farazi, JI Hoell, P Morozov, T Tuschl - MicroRNA cancer regulation …, 2013‏ - Springer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011‏ - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Non-coding RNAs in human disease

M Esteller - Nature reviews genetics, 2011‏ - nature.com
The relevance of the non-coding genome to human disease has mainly been studied in the
context of the widespread disruption of microRNA (miRNA) expression and function that is …

miRNAs in human cancer

TA Farazi, JI Spitzer, P Morozov… - The Journal of …, 2011‏ - Wiley Online Library
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 20–23 nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …

MicroRNA therapeutics

JA Broderick, PD Zamore - Gene therapy, 2011‏ - nature.com
MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad
roles in development and cellular processes make them fascinating to study. We still do not …

Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss

A Mencia, S Modamio-Høybjør, N Redshaw, M Morin… - Nature …, 2009‏ - nature.com
MicroRNAs (miRNAs) bind to complementary sites in their target mRNAs to mediate post-
transcriptional repression 1, 2, with the specificity of target recognition being crucially …