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Biology, vulnerabilities and clinical applications of circulating tumour cells
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …
Roles of macrophages in tumor development: a spatiotemporal perspective
Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …
Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds
HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …
Dynamic EMT: a multi‐tool for tumor progression
S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …
[HTML][HTML] TGF-β in developmental and fibrogenic EMTs
JH Lee, J Massagué - Seminars in cancer biology, 2022 - Elsevier
TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs)
during development and wound healing and in disease conditions such as fibrosis and …
during development and wound healing and in disease conditions such as fibrosis and …
Epithelial–mesenchymal transition in tissue repair and degeneration
KK Youssef, MA Nieto - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic
development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes …
development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes …
The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Guidelines and definitions for research on epithelial–mesenchymal transition
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …
Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …
Cancer metastasis: molecular mechanisms and clinical perspectives
Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …
shapes the course of disease for cancer patients and commonly determines its lethal …