Biology, vulnerabilities and clinical applications of circulating tumour cells

A Ring, BD Nguyen-Sträuli, A Wicki, N Aceto - Nature Reviews Cancer, 2023 - nature.com
In recent years, exceptional technological advances have enabled the identification and
interrogation of rare circulating tumour cells (CTCs) from blood samples of patients, leading …

Roles of macrophages in tumor development: a spatiotemporal perspective

M Bied, WW Ho, F Ginhoux, C Blériot - Cellular & molecular …, 2023 - nature.com
Macrophages are critical regulators of tissue homeostasis but are also abundant in the
tumor microenvironment (TME). In both primary tumors and metastases, such tumor …

Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Dynamic EMT: a multi‐tool for tumor progression

S Brabletz, H Schuhwerk, T Brabletz… - The EMBO journal, 2021 - embopress.org
The process of epithelial–mesenchymal transition (EMT) is fundamental for embryonic
morphogenesis. Cells undergoing it lose epithelial characteristics and integrity, acquire …

[HTML][HTML] TGF-β in developmental and fibrogenic EMTs

JH Lee, J Massagué - Seminars in cancer biology, 2022 - Elsevier
TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs)
during development and wound healing and in disease conditions such as fibrosis and …

Epithelial–mesenchymal transition in tissue repair and degeneration

KK Youssef, MA Nieto - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Epithelial–mesenchymal transitions (EMTs) are the epitome of cell plasticity in embryonic
development and cancer; during EMT, epithelial cells undergo dramatic phenotypic changes …

The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Guidelines and definitions for research on epithelial–mesenchymal transition

J Yang, P Antin, G Berx, C Blanpain… - … reviews Molecular cell …, 2020 - nature.com
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular
organization from epithelial to mesenchymal phenotypes, which leads to functional changes …

Novel therapeutic strategies: targeting epithelial–mesenchymal transition in colorectal cancer

N Zhang, AS Ng, S Cai, Q Li, L Yang, D Kerr - The Lancet Oncology, 2021 - thelancet.com
Epithelial–mesenchymal transition (EMT) is a process during which cells lose their epithelial
characteristics, for instance apical–basal cell polarity and cell–cell contact, and gain …

Cancer metastasis: molecular mechanisms and clinical perspectives

SU Khan, K Fatima, F Malik, H Kalkavan… - Pharmacology & …, 2023 - Elsevier
Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …