Multimorbidity, commonly defined as the presence of two or more chronic medical conditions
in an individual, 1 is associated with decreased quality of life, functional decline, and …

Background Many people with chronic disease have more than one chronic condition, which
is referred to as multimorbidity. The term comorbidity is also used but this is now taken to …

Background The escalating use of prescribed drugs has increasingly raised concerns about
polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially …

Importance Improving patient safety is at the forefront of policy and practice. While
considerable progress has been made in understanding the frequency, causes and …

Objective To identify the number of drug-disease and drug-drug interactions for exemplar
index conditions within National Institute of Health and Care Excellence (NICE) clinical …

Health services throughout the world strive to provide care to people when they are unwell
and assist them to stay well. Primary care services are increasingly at the heart of integrated …

ANALYSIS Page 1 Adapting clinical guidelines to take account of multimorbidity Care of patients
with multimorbidity could be improved if new technology is used to bring together guidelines …

Objectives To examine:(1) changes in polypharmacy in 1997, 2002, 2007 and 2012 and;(2)
changes in potentially inappropriate prescribing (PIP) prevalence and the relationship …

Objective To investigate whether polypharmacy is associated with a higher incidence of
frailty in a large cohort of North Americans during 8 years of follow-up. Design Longitudinal …

Background Because of ageing populations, the growth in the number of people with multi-
morbidity and greater compliance with disease-specific guidelines, polypharmacy is …