Cell death in liver diseases: a review
Regulated cell death (RCD) is pivotal in directing the severity and outcome of liver injury.
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Hepatocyte cell death is a critical event in the progression of liver disease due to resultant …
Roles of RIPK3 in necroptosis, cell signaling, and disease
Abstract Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …
“programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is …
Immunological mechanisms and therapeutic targets of fatty liver diseases
Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are the two major
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
types of chronic liver disease worldwide. Inflammatory processes play key roles in the …
Acetaminophen hepatotoxicity
Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide.
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
However, due to its wide availability, it is frequently implicated in intentional or unintentional …
Sublethal necroptosis signaling promotes inflammation and liver cancer
It is currently not well known how necroptosis and necroptosis responses manifest in vivo.
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Here, we uncovered a molecular switch facilitating reprogramming between two alternative …
Lytic cell death in metabolic liver disease
Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal
in governing outcomes of metabolic liver disease. Different types of cell death may coexist …
in governing outcomes of metabolic liver disease. Different types of cell death may coexist …
MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis
X Wu, KL Poulsen, C Sanz-Garcia, E Huang… - Journal of …, 2020 - Elsevier
Background & Aims Autophagy maintains cellular homeostasis and plays a critical role in
the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed …
the development of non-alcoholic fatty liver and steatohepatitis. The pseudokinase mixed …
MicroRNA-378 promotes hepatic inflammation and fibrosis via modulation of the NF-κB-TNFα pathway
T Zhang, J Hu, X Wang, X Zhao, Z Li, J Niu, CJ Steer… - Journal of …, 2019 - Elsevier
Background & Aims The progression of hepatosteatosis to non-alcoholic steatohepatitis
(NASH) is a critical step in the pathogenesis of hepatocellular cancer. However, the …
(NASH) is a critical step in the pathogenesis of hepatocellular cancer. However, the …
The role of protein kinases as key drivers of metabolic dysfunction-associated fatty liver disease progression: New insights and future directions
Metabolic dysfunction-associated fatty liver disease (MAFLD), proposed in 2020 is a novel
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …
term for non-alcoholic fatty liver disease (NAFLD) which was coined for the first time in 1980 …
Cell death in drug-induced liver injury
Drug-induced liver injury (DILI) is an important cause of liver toxicity which can have varying
clinical presentations, the most severe of which being acute liver failure. Hepatocyte death …
clinical presentations, the most severe of which being acute liver failure. Hepatocyte death …