The remarkable capacity of immunotherapies to induce durable regression in some patients
with metastatic cancer relies heavily on T cell recognition of tumor-presented antigens. As …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with
evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms …

Adequate reprogramming of cellular metabolism in response to stresses or suboptimal
growth conditions involves a myriad of coordinated changes that serve to promote cell …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …

Methionine in proteins, apart from its role in the initiation of translation, is assumed to play a
simple structural role in the hydrophobic core, in a similar way to other hydrophobic amino …

As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …

Missense mutations account for approximately 50% of pathogenic mutations in human
genetic diseases, and most lack effective treatments. Gene therapies, gene editing, and …

Although key tumorigenic and tumor-suppressive factors have been unveiled over the last
several decades, cancer remains the most life-threatening disease. Multiomic analyses of …

Methionine in proteins is often thought to be a generic hydrophobic residue, functionally
replaceable with another hydrophobic residue such as valine or leucine. This is not the …