Regulation of microRNA biogenesis
M Ha, VN Kim - Nature reviews Molecular cell biology, 2014 - nature.com
MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all …
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that direct widespread gene
repression in the cells of humans and other animals. Each miRNA associates with an …
repression in the cells of humans and other animals. Each miRNA associates with an …
[HTML][HTML] A network of noncoding regulatory RNAs acts in the mammalian brain
Noncoding RNAs (ncRNAs) play increasingly appreciated gene-regulatory roles. Here, we
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …
describe a regulatory network centered on four ncRNAs—a long ncRNA, a circular RNA …
Diversifying microRNA sequence and function
MicroRNAs (miRNAs) regulate the expression of most genes in animals, but we are only
now beginning to understand how they are generated, assembled into functional complexes …
now beginning to understand how they are generated, assembled into functional complexes …
MicroRNAs in liver disease
G Szabo, S Bala - Nature reviews Gastroenterology & hepatology, 2013 - nature.com
Small, noncoding microRNAs (miRNAs) regulate diverse biological functions in the liver and
increasing evidence suggests that they have a role in liver pathology. This Review …
increasing evidence suggests that they have a role in liver pathology. This Review …
Structural basis for target-directed microRNA degradation
MicroRNAs (miRNAs) broadly regulate gene expression through association with Argonaute
(Ago), which also protects miRNAs from degradation. However, miRNA stability is known to …
(Ago), which also protects miRNAs from degradation. However, miRNA stability is known to …
[HTML][HTML] Endogenous transcripts direct microRNA degradation in Drosophila, and this targeted degradation is required for proper embryonic development
ER Kingston, LW Blodgett, DP Bartel - Molecular cell, 2022 - cell.com
MicroRNAs (miRNAs) typically direct degradation of their mRNA targets. However, some
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …
targets have unusual miRNA-binding sites that direct degradation of cognate miRNAs …
Time-resolved small RNA sequencing unravels the molecular principles of microRNA homeostasis
Argonaute-bound microRNAs silence mRNA expression in a dynamic and regulated
manner to control organismal development, physiology, and disease. We employed …
manner to control organismal development, physiology, and disease. We employed …
Impact of microRNA levels, target-site complementarity, and cooperativity on competing endogenous RNA-regulated gene expression
Expression changes of competing endogenous RNAs (ceRNAs) have been proposed to
influence microRNA (miRNA) activity and thereby regulate other transcripts containing …
influence microRNA (miRNA) activity and thereby regulate other transcripts containing …