SARS-CoV-2: structure, biology, and structure-based therapeutics development

MY Wang, R Zhao, LJ Gao, XF Gao… - Frontiers in cellular …, 2020 - frontiersin.org
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has been posing great threats to the world in many aspects. Effective therapeutic and …

A Review of the Progress and Challenges of Develo** a Vaccine for COVID-19

O Sharma, AA Sultan, H Ding, CR Triggle - Frontiers in immunology, 2020 - frontiersin.org
A novel coronavirus, which has been designated as severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), was first detected in December 2019 in Wuhan China and …

Structures and distributions of SARS-CoV-2 spike proteins on intact virions

Z Ke, J Oton, K Qu, M Cortese, V Zila, L McKeane… - Nature, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virions are surrounded by
a lipid bilayer from which spike (S) protein trimers protrude. Heavily glycosylated S trimers …

[HTML][HTML] Structures of human antibodies bound to SARS-CoV-2 spike reveal common epitopes and recurrent features of antibodies

CO Barnes, AP West, KE Huey-Tubman… - Cell, 2020 - cell.com
Neutralizing antibody responses to coronaviruses mainly target the receptor-binding domain
(RBD) of the trimeric spike. Here, we characterized polyclonal immunoglobulin Gs (IgGs) …

[HTML][HTML] Multi-system inflammatory syndrome in children (MIS-C) following SARS-CoV-2 infection: review of clinical presentation, hypothetical pathogenesis, and …

NA Nakra, DA Blumberg, A Herrera-Guerra… - Children, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the
multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C …

Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis

AM Kotlyar, O Grechukhina, A Chen… - American journal of …, 2021 - Elsevier
Objective This study aimed to conduct a systematic review of the current literature to
determine estimates of vertical transmission of coronavirus disease 2019 based on early …

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity

L Zhang, CB Jackson, H Mou, A Ojha… - BioRxiv, 2020 - pmc.ncbi.nlm.nih.gov
SARS coronavirus 2 (SARS-CoV-2) isolates encoding a D614G mutation in the viral spike
(S) protein predominate over time in locales where it is found, implying that this change …

The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2

S Muralidar, SV Ambi, S Sekaran, UM Krishnan - Biochimie, 2020 - Elsevier
An acute respiratory disease caused by a severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) that surfaced in China in late 2019, continues to spread rapidly across the …

Mutations strengthened SARS-CoV-2 infectivity

J Chen, R Wang, M Wang, GW Wei - Journal of molecular biology, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is a major
concern in coronavirus disease 2019 (COVID-19) prevention and economic reopening …

Epidemiological and clinical characteristics of the COVID-19 epidemic in Brazil

WM de Souza, LF Buss, DS Candido… - Nature human …, 2020 - nature.com
The first case of COVID-19 was detected in Brazil on 25 February 2020. We report and
contextualize epidemiological, demographic and clinical findings for COVID-19 cases during …