Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Recent advances in the application of metabolomics for food safety control and food quality analyses

S Li, Y Tian, P Jiang, Y Lin, X Liu… - Critical reviews in food …, 2021 - Taylor & Francis
As one of the omics fields, metabolomics has unique advantages in facilitating the
understanding of physiological and pathological activities in biology, physiology, pathology …

In-cell structural biology by NMR: the benefits of the atomic scale

FX Theillet - Chemical reviews, 2022 - ACS Publications
In-cell structural biology aims at extracting structural information about proteins or nucleic
acids in their native, cellular environment. This emerging field holds great promise and is …

Guide to metabolomics analysis: a bioinformatics workflow

Y Chen, EM Li, LY Xu - Metabolites, 2022 - mdpi.com
Metabolomics is an emerging field that quantifies numerous metabolites systematically. The
key purpose of metabolomics is to identify the metabolites corresponding to each biological …

Nuclear magnetic resonance spectroscopy in clinical metabolomics and personalized medicine: current challenges and perspectives

MPM Letertre, P Giraudeau, P De Tullio - Frontiers in Molecular …, 2021 - frontiersin.org
Personalized medicine is probably the most promising area being developed in modern
medicine. This approach attempts to optimize the therapies and the patient care based on …

Metabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab

G Meoni, V Ghini, L Maggi, A Vignoli, A Mazzoni… - PLoS …, 2021 - journals.plos.org
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a
relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of …

Serum or plasma (and which plasma), that is the question

A Vignoli, L Tenori, C Morsiani, P Turano… - Journal of proteome …, 2022 - ACS Publications
Blood derivatives are the biofluids of choice for metabolomic clinical studies since blood can
be collected with low invasiveness and is rich in biological information. However, the choice …

Studying metabolism by NMR-based metabolomics

S Moco - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
During the past few decades, the direct analysis of metabolic intermediates in biological
samples has greatly improved the understanding of metabolic processes. The most used …

NMR metabolomics methods for investigating disease

GA Nagana Gowda, D Raftery - Analytical chemistry, 2023 - ACS Publications
The field of metabolomics continues to grow exponentially as it contributes significantly to
numerous disciplines, including biomedicine, pharmacology, drug development, and …

Quantitative NMR-based biomedical metabolomics: Current status and applications

AA Crook, R Powers - Molecules, 2020 - mdpi.com
Nuclear Magnetic Resonance (NMR) spectroscopy is a quantitative analytical tool
commonly utilized for metabolomics analysis. Quantitative NMR (qNMR) is a field of NMR …