Platelet metabolic flexibility: a matter of substrate and location

S Ravera, MG Signorello, I Panfoli - Cells, 2023 - mdpi.com
Platelets are cellular elements that are physiologically involved in hemostasis, inflammation,
thrombotic events, and various human diseases. There is a link between the activation of …

Regulation of mitochondrial function by hydroquinone derivatives as prevention of platelet activation

E Fuentes, D Arauna, R Araya-Maturana - Thrombosis Research, 2023 - Elsevier
Platelet activation plays an essential role in the pathogenesis of thrombotic events in
different diseases (eg, cancer, type 2 diabetes, Alzheimer's, and cardiovascular diseases …

[HTML][HTML] Effect of Oxidative Stress on Mitochondrial Damage and Repair in Heart Disease and Ischemic Events

P Kowalczyk, S Krych, K Kramkowski… - International …, 2024 - pmc.ncbi.nlm.nih.gov
The literature analysis conducted in this review discusses the latest achievements in the
identification of cardiovascular damage induced by oxidative stress with secondary platelet …

Platelet Metabolic Profiling Reveals Glycolytic and 1-Carbon Metabolites Are Essential for GP VI–Stimulated Human Platelets—Brief Report

M Ghatge, GD Flora, MK Nayak… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Evolving evidence suggests that besides signaling pathways, platelet
activation involves a complex interplay between metabolic pathways to support thrombus …

Deep learning, 3D ultrastructural analysis reveals quantitative differences in platelet and organelle packing in COVID-19/SARSCoV2 patient-derived platelets

SS Matharu, CS Nordmann, KR Ottman, R Akkem… - Platelets, 2023 - Taylor & Francis
Platelets contribute to COVID-19 clinical manifestations, of which microclotting in the
pulmonary vasculature has been a prominent symptom. To investigate the potential …

IRAP Drives Ribosomal Degradation to Refuel Energy for Platelet Activation during Septic Thrombosis

B Xu, X Ye, K Sun, L Chen, Z Wen, Q Lan… - Advanced …, 2025 - Wiley Online Library
Platelets play crucial roles in multiple pathophysiological processes after energy‐dependent
activation. It is puzzling how such a small cellular debris has abundant energy supply. In this …

Inhibition of platelet activation process upon tris (2-chloroethyl) phosphate exposure: Role of PFKP-mediated glycolysis and the pentose phosphate pathway

Z Li, P Chen, Y Lin, J Zhang, J Ding, RZ Ahmed… - Environmental …, 2025 - Elsevier
ABSTRACT Tris (2-chloroethyl) phosphate (TCEP), recognized as an emerging pollutant,
has been frequently detected in human blood. Maintenance of blood homeostasis is …

Altered dynamics of calcium fluxes and mitochondrial metabolism in platelet activation-related disease and aging

D Arauna, R Araya-Maturana, FA Urra, Á García… - Life Sciences, 2024 - Elsevier
Understanding the mechanisms controlling platelet function is crucial for exploring potential
therapeutic targets related to atherothrombotic pathologies and primary hemostasis …

[HTML][HTML] Platelet lipidomics and de novo lipogenesis: impact on health and disease

L Pirotton, E de Cartier d'Yves, L Bertrand… - Current Opinion in …, 2024 - journals.lww.com
Platelet lipidomics and de novo lipogenesis: impact on healt... : Current Opinion in
Hematology Platelet lipidomics and de novo lipogenesis: impact on health and disease …

New Dimension to Study on Platelet Bioenergetics

D Dash - Arteriosclerosis, Thrombosis, and Vascular Biology, 2024 - Am Heart Assoc
Within their limited life span (10–12 days in humans and 4–5 days in mice), platelets
traverse through the alleys and sub-alleys of blood vessels with an onerous mandate to …