Review of technological challenges in personalised medicine and early diagnosis of neurodegenerative disorders

C Domínguez-Fernández, J Egiguren-Ortiz… - International Journal of …, 2023 - mdpi.com
Neurodegenerative disorders are characterised by progressive neuron loss in specific brain
areas. The most common are Alzheimer's disease and Parkinson's disease; in both cases …

Diffusion tensor imaging in amyotrophic lateral sclerosis: machine learning for biomarker development

A Behler, HP Müller, AC Ludolph… - International journal of …, 2023 - mdpi.com
Diffusion tensor imaging (DTI) allows the in vivo imaging of pathological white matter
alterations, either with unbiased voxel-wise or hypothesis-guided tract-based analysis …

Brain imaging and neuropsychological assessment of individuals recovered from a mild to moderate SARS-CoV-2 infection

M Petersen, FL Nägele, C Mayer… - Proceedings of the …, 2023 - National Acad Sciences
As severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infections have
been shown to affect the central nervous system, the investigation of associated alterations …

DNA origami-templated gold nanorod dimer nanoantennas: enabling addressable optical hotspots for single cancer biomarker SERS detection

M Sharma, C Kaur, P Singhmar, S Rai, T Sen - Nanoscale, 2024 - pubs.rsc.org
The convergence of DNA origami and surface-enhanced Raman spectroscopy (SERS) has
opened a new avenue in bioanalytical sciences, particularly in the detection of single …

DTI-ALPS: An MR biomarker for motor dysfunction in patients with subacute ischemic stroke

Y Qin, X Li, Y Qiao, H Zou, Y Qian, X Li, Y Zhu… - Frontiers in …, 2023 - frontiersin.org
Purpose Brain glymphatic dysfunction is involved in the pathologic process of acute
ischemic stroke (IS). The relationship between brain glymphatic activity and dysfunction in …

Neuroinflammation and mitochondrial dysfunction in parkinson's disease: connecting neuroimaging with pathophysiology

BM Pizarro-Galleguillos, L Kunert, N Brüggemann… - Antioxidants, 2023 - mdpi.com
There is a pressing need for disease-modifying therapies in patients suffering from
neurodegenerative diseases, including Parkinson's disease (PD). However, these disorders …

Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer's disease and Parkinson's disease

CP Lin, I Frigerio, JGJM Bol, MMA Bouwman… - Translational …, 2024 - Springer
Background Degeneration of the locus coeruleus (LC) noradrenergic system contributes to
clinical symptoms in Alzheimer's disease (AD) and Parkinson's disease (PD). Diffusion …

Gray Matter Volume Loss in Proposed Brain‐First and Body‐First Parkinson's Disease Subtypes

M Banwinkler, V Dzialas… - Movement …, 2022 - Wiley Online Library
Background α‐Synuclein pathology is associated with neuronal degeneration in Parkinson's
disease (PD) and considered to sequentially spread across the brain (Braak stages) …

Unveiling the future: advancements in MRI imaging for neurodegenerative disorders

L Du, S Roy, P Wang, Z Li, X Qiu, Y Zhang… - Ageing Research …, 2024 - Elsevier
Neurodegenerative disorders represent a significant and growing global health challenge,
necessitating continuous advancements in diagnostic tools for accurate and early detection …

[HTML][HTML] Microstructural white matter abnormalities in multiple sclerosis and neuromyelitis optica spectrum disorders: Evaluation by advanced diffusion imaging

S Kato, A Hagiwara, K Yokoyama, C Andica… - Journal of the …, 2022 - Elsevier
Introduction Despite differences in the pathogenesis and treatment of multiple sclerosis (MS)
and neuromyelitis optica spectrum disorders (NMOSD), it remains difficult to distinguish …