How vascular smooth muscle cell phenotype switching contributes to vascular disease
G Cao, X Xuan, J Hu, R Zhang, H **… - Cell Communication and …, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
experiments have found that VSMCs possess high plasticity. Vascular injury stimulates …
Ageing and atherosclerosis: vascular intrinsic and extrinsic factors and potential role of IL-6
The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …
Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications
R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
injury in many tissues. Although the extracellular matrix deposition appears unstructured …
Inflammation and fibrosis
M Mack - Matrix Biology, 2018 - Elsevier
Tissue damage and inflammation are important triggers for regeneration and fibrosis. Tissue
damage not only induces inflammation in general, it also determines the type and …
damage not only induces inflammation in general, it also determines the type and …
Vascular remodelling in cardiovascular diseases: hypertension, oxidation, and inflammation
J Totoń-Żurańska, TP Mikolajczyk, B Saju… - Clinical …, 2024 - portlandpress.com
Optimal vascular structure and function are essential for maintaining the physiological
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …
functions of the cardiovascular system. Vascular remodelling involves changes in vessel …
The role of vascular smooth muscle cells in arterial remodeling: focus on calcification-related processes
Arterial remodeling refers to the structural and functional changes of the vessel wall that
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
occur in response to disease, injury, or aging. Vascular smooth muscle cells (VSMC) play a …
Immune and inflammatory mechanisms in hypertension
TJ Guzik, R Nosalski, P Maffia… - Nature Reviews …, 2024 - nature.com
Hypertension is a global health problem, with> 1.3 billion individuals with high blood
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …
pressure worldwide. In this Review, we present an inflammatory paradigm for hypertension …
Differentiated smooth muscle cells generate a subpopulation of resident vascular progenitor cells in the adventitia regulated by Klf4
Rationale: The vascular adventitia is a complex layer of the vessel wall consisting of vasa
vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells …
vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells …
Extracellular matrix remodeling in vascular disease: defining its regulators and pathological influence
PK Lin, GE Davis - Arteriosclerosis, Thrombosis, and Vascular …, 2023 - Am Heart Assoc
Because of structural and cellular differences (ie, degrees of matrix abundance and cross-
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …
linking, mural cell density, and adventitia), large and medium-sized vessels, in comparison …