Cell-based strategies for IVD repair: clinical progress and translational obstacles
ALA Binch, JC Fitzgerald, EA Growney… - Nature Reviews …, 2021 - nature.com
Intervertebral disc (IVD) degeneration is a major cause of low back pain, a prevalent and
chronic condition that has a striking effect on quality of life. Currently, no approved …
chronic condition that has a striking effect on quality of life. Currently, no approved …
Non-viral delivery of nucleic acids: insight into mechanisms of overcoming intracellular barriers
Delivery of genes, including plasmid DNAs, short interfering RNAs (siRNAs), and
messenger RNAs (mRNAs), using artificial non-viral nanotherapeutics is a promising …
messenger RNAs (mRNAs), using artificial non-viral nanotherapeutics is a promising …
Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy
A plethora of biological barriers, intended to defend tissues and cells against external
influences, stand in the way of efficient nucleic acid delivery by non-viral nanoplexes. Even …
influences, stand in the way of efficient nucleic acid delivery by non-viral nanoplexes. Even …
Subcellular trafficking and transfection efficacy of polyethylenimine–polyethylene glycol polyplex nanoparticles with a ligand to melanocortin receptor-1
We have synthesized and investigated properties of new PEI–PEG-based polyplexes
containing MC1SP-peptide, a ligand specific for melanocortin receptor-1 (targeted …
containing MC1SP-peptide, a ligand specific for melanocortin receptor-1 (targeted …
Removing barriers and disparities in health: lessons from the COVID-19 pandemic
The COVID-19 pandemic has compelled the global community to work together to
understand SARS-CoV-2 and mitigate its effects, but it has also highlighted health …
understand SARS-CoV-2 and mitigate its effects, but it has also highlighted health …
Live imaging of transgene expression in Cloudman S91 melanoma cells after polyplex-mediated gene delivery
MO Durymanov, AV Yarutkin, YV Khramtsov… - Journal of Controlled …, 2015 - Elsevier
Utilizing nanoparticles made of cationic polymers as gene carriers is a promising approach
in cancer gene therapy. One of the major requirements for successful gene delivery is DNA …
in cancer gene therapy. One of the major requirements for successful gene delivery is DNA …
Polyethylenimine-based polyplex nanoparticles and features of their behavior in cells and tissues
The design of efficient systems for the targeted delivery of nucleic acids into cells is a rapidly
develo** area of polymer chemistry, molecular biology, and medicine. Complexes …
develo** area of polymer chemistry, molecular biology, and medicine. Complexes …
Application of vasoactive and matrix-modifying drugs can improve polyplex delivery to tumors upon intravenous administration
Low efficacy of cationic polymer-based formulations (polyplexes) for systemic gene delivery
to tumors remains the crucial concern for their clinical translation. Here we show that …
to tumors remains the crucial concern for their clinical translation. Here we show that …
[PDF][PDF] ДОСТАВКА БИОМОЛЕКУЛ В КЛЕТКИ С ИСПОЛЬЗОВАНИЕМ СЛОЕВ НАНОЧАСТИЦ ЗОЛОТА И ИНФРАКРАСНОГО ЛАЗЕРНОГО ОБЛУЧЕНИЯ
ЕС АВДЕЕВА - science.vsu.ru
Генная терапия является одной из наиболее перспективных и активно изучаемых
современных технологий, которая открывает новые возможности в медицине, делая …
современных технологий, которая открывает новые возможности в медицине, делая …