Because of the ability to recapitulate normal developmental processes, brain organoids
derived from pluripotent stem cells are an important experimental resource to investigate the …

We previously demonstrated that mouse embryonic stem cell (mESC)-derived retinal
epithelium self-forms an optic cup-like structure. In the develo** retina, the dorsal and …

Limb development starts with the formation of limb buds (LBs), which consist of tissues from
two different germ layers; the lateral plate mesoderm-derived mesenchyme and ectoderm …

A three-dimensional retinal tissue (3D-retina) is a promising graft source for retinal
transplantation therapy. We previously demonstrated that embryonic stem cells (ESCs) can …

Effective derivation of three-dimensional (3D) retinal tissue from human-induced pluripotent
stem cells (hiPSCs) could provide models for drug screening and facilitate patient-specific …

Bipolar disorder (BP) is a complex psychiatric condition characterized by severe fluctuations
in mood for which underlying pathological mechanisms remain unclear. Family and twin …

The eyes are subdivided from the rostral diencephalon in early development. How the
neuroectoderm regulates this subdivision, however, is largely unknown. Taking advantage …

Insulin-like growth factors (IGFs) are involved in growth and tissue development, including
diseases such as type-2 diabetes and cancers. However, their roles in lineage specification …

The advance of stem cell research has enabled researchers to generate organoids: three-
dimensional tissues with biological structures and functions. By application of organoid …

This article contains data related to the research article entitled “Specification of embryonic
stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue …