Borderline HbA2 levels: dilemma in diagnosis of beta-thalassemia carriers

S Colaco, A Nadkarni - Mutation Research/Reviews in Mutation Research, 2021 - Elsevier
There is inconsistency in the exact definition of diagnostic levels of HbA 2 for β thalassemia
trait. While many laboratories consider HbA 2≥ 4.0% diagnostic, still others consider HbA …

[HTML][HTML] Differentiation of beta thalassemia trait from iron deficiency anemia by hematological indices

T Jameel, M Baig, I Ahmed, MB Hussain… - Pakistan journal of …, 2017 - ncbi.nlm.nih.gov
Objective: We aimed at finding out reliable parameter in the differentiation of iron deficiency
anemia (IDA) and beta-thalassemia trait (β-TT) in the adult population subjected to Saudi …

Discrimination of β-thalassemia and iron deficiency anemia through extreme learning machine and regularized extreme learning machine based decision support …

B Çil, H Ayyıldız, T Tuncer - Medical hypotheses, 2020 - Elsevier
Abstract The symptoms of Iron Deficiency Anemia (IDA) and β-thalassemia (β-TT) disease
are similar and the distinction between them is time consuming and costly. There are several …

Unresolved laboratory issues of the heterozygous state of β-thalassemia: A literature review

S Thilakarathne, UP Jayaweera… - …, 2023 - pmc.ncbi.nlm.nih.gov
Although considered a mild clinical condition, many laboratory issues of the carrier state of β-
thalassemia remain unresolved. Accurate laboratory screening of β-thalassemia traits is …

[HTML][HTML] Undiagnosed hemoglobinopathies: a potential threat to the premarital screening program

HA Hamali, M Saboor - Pakistan journal of medical sciences, 2019 - ncbi.nlm.nih.gov
Objectives: To evaluate the prevalence of undiagnosed hemoglobinopathies among
individuals visiting the premarital screening Centre. Methods: This study was conducted at …

ThalPred: a web-based prediction tool for discriminating thalassemia trait and iron deficiency anemia

V Laengsri, W Shoombuatong, W Adirojananon… - BMC medical informatics …, 2019 - Springer
Background The hypochromic microcytic anemia (HMA) commonly found in Thailand are
iron deficiency anemia (IDA) and thalassemia trait (TT). Accurate discrimination between …

Hemoglobin A2 (HbA2) has a measure of unreliability in diagnosing β-thalassemia trait (β-TT)

AM Al-Amodi, NZ Ghanem, SA Aldakeel… - … medical research and …, 2018 - Taylor & Francis
Introduction: Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an
increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (< 3%) in normal …

[HTML][HTML] Spectrum of hemoglobinopathies with hematological and biochemical profile: A five year experience from a tertiary care hospital

N Mansoor, F Meraj, A Shaikh… - Pakistan Journal of …, 2022 - ncbi.nlm.nih.gov
Methods: This retrospective study included results of high performance liquid
chromatography (HPLC) test from July 2015-May 2020 in the department of Hematology …

Screening of extended family members of thalassemia major children as a thalassemia preventive strategy

ND Sonkawade, AA Kinikar, RK Kulkarni… - Ethiopian Journal of …, 2022 - ajol.info
BACKGROUND: Thalassemia is considered as the most common single gene disorder
worldwide. Preventive measures include identification of thalassemia carriers (traits) through …

Candidate SNP Markers of Chronopathologies Are Predicted by a Significant Change in the Affinity of TATA‐Binding Protein for Human Gene Promoters

P Ponomarenko, D Rasskazov, V Suslov… - BioMed Research …, 2016 - Wiley Online Library
Variations in human genome (eg, single nucleotide polymorphisms, SNPs) may be
associated with hereditary diseases, their complications, comorbidities, and drug responses …