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Potential therapeutic targets to modulate the endocannabinoid system in Alzheimer's disease
H Kanwal, M Sangineto, M Ciarnelli… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the most common neurodegenerative disease (NDD), is
characterized by chronic neuronal cell death through progressive loss of cognitive function …
characterized by chronic neuronal cell death through progressive loss of cognitive function …
Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease
Abstract Cannabinoid CB 2 receptors (CB 2 Rs) are emerging as important therapeutic
targets in brain disorders that typically involve neurometabolic alterations. We here …
targets in brain disorders that typically involve neurometabolic alterations. We here …
Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain
C Lemos, BS Pinheiro, RO Beleza, JM Marques… - Purinergic …, 2015 - Springer
ATP consumption during intense neuronal activity leads to peaks of both extracellular
adenosine levels and increased glucose uptake in the brain. Here, we investigated the …
adenosine levels and increased glucose uptake in the brain. Here, we investigated the …
Methamphetamine induces anhedonic‐like behavior and impairs frontal cortical energetics in mice
R Fonseca, RA Carvalho, C Lemos… - CNS Neuroscience …, 2017 - Wiley Online Library
Introduction We recently showed that a single high dose of methamphetamine (METH)
induces a persistent frontal cortical monoamine depletion that is accompanied by helpless …
induces a persistent frontal cortical monoamine depletion that is accompanied by helpless …
Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin
BS Pinheiro, C Lemos, FN Kaufmann, JM Marques… - Brain research …, 2016 - Elsevier
Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …
Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain
Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis
via convergent signaling pathways that are impacted by diabetes. Here we asked how …
via convergent signaling pathways that are impacted by diabetes. Here we asked how …
Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes
JR Pedro, LIF Moura, Â Valério-Fernandes… - Brain research …, 2020 - Elsevier
Here we aimed to unify some previous controversial reports on changes in both cannabinoid
CB 1 receptor (CB 1 R) expression and glucose metabolism in the forebrain of rodent …
CB 1 receptor (CB 1 R) expression and glucose metabolism in the forebrain of rodent …
[PDF][PDF] Supplemental files to: Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 …
JR Pedro, LIF Moura, Â Valério-Fernandes, FI Baptista… - researchgate.net
SFigure 1. Body weight and blood glucose levels of diabetic and control rats.(A) Initial
weight of the sham and diabetic animals were not significantly different.(B) glycemia values …
weight of the sham and diabetic animals were not significantly different.(B) glycemia values …
Metabolic modifications associated with memory deficits
ACFL Rial - 2016 - baes.uc.pt
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
Metabolic modifications associated with memory deficits
ACF de Lemos - 2016 - search.proquest.com
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …