Potential therapeutic targets to modulate the endocannabinoid system in Alzheimer's disease

H Kanwal, M Sangineto, M Ciarnelli… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD), the most common neurodegenerative disease (NDD), is
characterized by chronic neuronal cell death through progressive loss of cognitive function …

Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

A Köfalvi, C Lemos, AM Martín-Moreno, BS Pinheiro… - …, 2016 - Elsevier
Abstract Cannabinoid CB 2 receptors (CB 2 Rs) are emerging as important therapeutic
targets in brain disorders that typically involve neurometabolic alterations. We here …

Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain

C Lemos, BS Pinheiro, RO Beleza, JM Marques… - Purinergic …, 2015 - Springer
ATP consumption during intense neuronal activity leads to peaks of both extracellular
adenosine levels and increased glucose uptake in the brain. Here, we investigated the …

Methamphetamine induces anhedonic‐like behavior and impairs frontal cortical energetics in mice

R Fonseca, RA Carvalho, C Lemos… - CNS Neuroscience …, 2017 - Wiley Online Library
Introduction We recently showed that a single high dose of methamphetamine (METH)
induces a persistent frontal cortical monoamine depletion that is accompanied by helpless …

Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin

BS Pinheiro, C Lemos, FN Kaufmann, JM Marques… - Brain research …, 2016 - Elsevier
Here we asked if insulin activation of the nucleus accumbens in vitro is reflected by an
increase in 3 H-deoxyglucose ([3 H] DG) uptake, thus subserving a new model to study …

Chronic insulinopenia/hyperglycemia decreases cannabinoid CB1 receptor density and impairs glucose uptake in the mouse forebrain

LIF Moura, C Lemos, C Ledent, E Carvalho… - Brain research …, 2019 - Elsevier
Both endocannabinoids and insulin regulate peripheral and cerebral glucose homeostasis
via convergent signaling pathways that are impacted by diabetes. Here we asked how …

Transient gain of function of cannabinoid CB1 receptors in the control of frontocortical glucose consumption in a rat model of Type-1 diabetes

JR Pedro, LIF Moura, Â Valério-Fernandes… - Brain research …, 2020 - Elsevier
Here we aimed to unify some previous controversial reports on changes in both cannabinoid
CB 1 receptor (CB 1 R) expression and glucose metabolism in the forebrain of rodent …

[PDF][PDF] Supplemental files to: Transient Gain of Function of Cannabinoid CB1 Receptors in the Control of Frontocortical Glucose Consumption in a Rat Model of Type-1 …

JR Pedro, LIF Moura, Â Valério-Fernandes, FI Baptista… - researchgate.net
SFigure 1. Body weight and blood glucose levels of diabetic and control rats.(A) Initial
weight of the sham and diabetic animals were not significantly different.(B) glycemia values …

Metabolic modifications associated with memory deficits

ACFL Rial - 2016 - baes.uc.pt
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …

Metabolic modifications associated with memory deficits

ACF de Lemos - 2016 - search.proquest.com
This work started from the known premise that, in the brain, glucose availability regulates
memory and cognition in both healthy humans and dementia patients. Furthermore, cerebral …