Models of psychedelic drug action: modulation of cortical-subcortical circuits
Classic psychedelic drugs such as psilocybin and lysergic acid diethylamide (LSD) have
recaptured the imagination of both science and popular culture, and may have efficacy in …
recaptured the imagination of both science and popular culture, and may have efficacy in …
Sex differences in neural mechanisms mediating reward and addiction
There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …
differences in every phase of drug addiction: acute reinforcing effects, transition from …
Attenuation of antidepressant effects of ketamine by opioid receptor antagonism
Objective: In addition to N-methyl-d-aspartate receptor antagonism, ketamine produces
opioid system activation. The objective of this study was to determine whether opioid …
opioid system activation. The objective of this study was to determine whether opioid …
A randomized proof-of-mechanism trial applying the 'fast-fail'approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Abstract The National Institute of Mental Health (NIMH)'fast-fail'approach seeks to improve
too-often-misleading early-phase drug development methods by incorporating biomarker …
too-often-misleading early-phase drug development methods by incorporating biomarker …
[HTML][HTML] Looking for the self: phenomenology, neurophysiology and philosophical significance of drug-induced ego dissolution
R Millière - Frontiers in human neuroscience, 2017 - frontiersin.org
There is converging evidence that high doses of hallucinogenic drugs can produce
significant alterations of self-experience, described as the dissolution of the sense of self …
significant alterations of self-experience, described as the dissolution of the sense of self …
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis
In this review we propose that there are sex differences in how men and women enter onto
the path that can lead to addiction. Males are more likely than females to engage in risky …
the path that can lead to addiction. Males are more likely than females to engage in risky …
Clinical applications of hallucinogens: A review.
A Garcia-Romeu, B Kersgaard… - Experimental and clinical …, 2016 - psycnet.apa.org
Hallucinogens fall into several different classes, as broadly defined by pharmacological
mechanism of action, and chemical structure. These include psychedelics, entactogens …
mechanism of action, and chemical structure. These include psychedelics, entactogens …
Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant
ECD Gonçalves, GM Baldasso, MA Bicca, RS Paes… - Molecules, 2020 - mdpi.com
Medicinal use of Cannabis sativa L. has an extensive history and it was essential in the
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …
discovery of phytocannabinoids, including the Cannabis major psychoactive compound—Δ9 …
[HTML][HTML] The kappa opioid receptor: from addiction to depression, and back
Comorbidity is a major issue in psychiatry that notably associates with more severe
symptoms, longer illness duration, and higher service utilization. Therefore, identifying key …
symptoms, longer illness duration, and higher service utilization. Therefore, identifying key …
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology
YJ Wang, GY Zan, C Xu, XP Li, X Shu, SY Yao… - Nature …, 2023 - nature.com
Ample evidence has suggested the stress etiology of depression, but the underlying
mechanism is not fully understood yet. Here, we report that chronic social defeat stress …
mechanism is not fully understood yet. Here, we report that chronic social defeat stress …