TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Globally, prostate cancer (PCa) is regarded as a challenging health issue, and the number
of PCa patients continues to rise despite the availability of effective treatments in recent …

The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in malignant
transformation, prevention of apoptosis, drug resistance and metastasis. The expression of …

Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate
adenocarcinoma (AdPC) cells and acts as a target for molecular imaging. However, some …

Poly-ADP ribose polymerase (PARP) inhibitors are currently used in the treatment of several
cancers carrying mutations in the breast and ovarian cancer susceptibility genes BRCA1 …

Prostate cancer harboring BRCA1/2 mutations are often exceptionally sensitive to PARP
inhibitors. However, genomic alterations in other DNA damage response genes have not …

Aneuploidy, defined as whole chromosome gains and losses, is associated with poor patient
prognosis in many cancer types. However, the condition causes cellular stress and cell cycle …

Inadequate nutrient intake leads to oxidative stress disrupting homeostasis, activating
signaling, and altering metabolism. Oxidative stress serves as a hallmark in develo** …