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Modulation of cellular processes by histone and non-histone protein acetylation
Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …
BRD4 and Cancer: going beyond transcriptional regulation
B Donati, E Lorenzini, A Ciarrocchi - Molecular cancer, 2018 - Springer
BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …
Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation
Precise spatio–temporal control of gene activity is essential for organismal development,
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
growth, and survival in a changing environment. Decisive steps in gene regulation involve …
[HTML][HTML] Liquid nuclear condensates mechanically sense and restructure the genome
Phase transitions involving biomolecular liquids are a fundamental mechanism underlying
intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically …
intracellular organization. In the cell nucleus, liquid-liquid phase separation of intrinsically …
New insights into the immunopathogenesis of systemic lupus erythematosus
The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …
Born to run: control of transcription elongation by RNA polymerase II
The dynamic regulation of transcription elongation by RNA polymerase II (Pol II) is an
integral part of the implementation of gene expression programmes during development. In …
integral part of the implementation of gene expression programmes during development. In …
Enhancers as non-coding RNA transcription units: recent insights and future perspectives
Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …
Diversity and emerging roles of enhancer RNA in regulation of gene expression and cell fate
Enhancers are cis-regulatory elements in the genome that cooperate with promoters to
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …
control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent …
The bromodomain and extra-terminal domain (BET) family: functional anatomy of BET paralogous proteins
Y Taniguchi - International journal of molecular sciences, 2016 - mdpi.com
The Bromodomain and Extra-Terminal Domain (BET) family of proteins is characterized by
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …
the presence of two tandem bromodomains and an extra-terminal domain. The mammalian …
Clinical response of carcinomas harboring the BRD4–NUT oncoprotein to the targeted bromodomain inhibitor OTX015/MK-8628
The antineoplastic, prodifferentiative effects of bromodomain and extra-terminal (BET)
bromodomain (BRD) inhibitors were initially discovered in NUT midline carcinoma (NMC) …
bromodomain (BRD) inhibitors were initially discovered in NUT midline carcinoma (NMC) …