Tumor glycolysis, an essential sweet tooth of tumor cells
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
Metabolic heterogeneity in cancer
Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
tumour metabolic heterogeneity arises and develops in response to diverse environmental …
Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the
mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag …
mechanism by which lactate exerts its effect remains elusive. Using RNA-seq and CUT&Tag …
CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
A high-fat diet (HFD) promotes metastasis through increased uptake of saturated fatty acids
(SFAs). The fatty acid transporter CD36 has been implicated in this process, but a detailed …
(SFAs). The fatty acid transporter CD36 has been implicated in this process, but a detailed …
[HTML][HTML] Nrf2 modulation in breast cancer
Reactive oxygen species (ROS) are identified to control the expression and activity of
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …
various essential signaling intermediates involved in cellular proliferation, apoptosis, and …
HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence
M Cui, K Yamano, K Yamamoto… - Proceedings of the …, 2024 - pnas.org
Mitochondrial and lysosomal functions are intimately linked and are critical for cellular
homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple …
homeostasis, as evidenced by the fact that cellular senescence, aging, and multiple …
Degradation of hexokinase 2 blocks glycolysis and induces GSDME-dependent pyroptosis to amplify immunogenic cell death for breast cancer therapy
R Sang, R Fan, A Deng, J Gou, R Lin… - Journal of Medicinal …, 2023 - ACS Publications
Hexokinase 2 (HK2) is the principal rate-limiting enzyme in the aerobic glycolysis pathway
and determines the quantity of glucose entering glycolysis. However, the current HK2 …
and determines the quantity of glucose entering glycolysis. However, the current HK2 …
Cancer immunometabolism: advent, challenges, and perspective
Q Dang, B Li, B **, Z Ye, X Lou, T Wang, Y Wang… - Molecular Cancer, 2024 - Springer
For decades, great strides have been made in the field of immunometabolism. A plethora of
evidence ranging from basic mechanisms to clinical transformation has gradually embarked …
evidence ranging from basic mechanisms to clinical transformation has gradually embarked …
Metabolic signaling in cancer metastasis
S Krieg, SI Fernandes, C Kolliopoulos, M Liu… - Cancer …, 2024 - aacrjournals.org
Metastases, which are the leading cause of death in patients with cancer, have metabolic
vulnerabilities. Alterations in metabolism fuel the energy and biosynthetic needs of …
vulnerabilities. Alterations in metabolism fuel the energy and biosynthetic needs of …
Role of glucose metabolic reprogramming in breast cancer progression and drug resistance
P Lei, W Wang, M Sheldon, Y Sun, F Yao, L Ma - Cancers, 2023 - mdpi.com
Simple Summary Glucose metabolic reprogramming is a process in which cells alter the way
that glucose is utilized. In breast cancer, cells can undergo this process to fuel their growth …
that glucose is utilized. In breast cancer, cells can undergo this process to fuel their growth …