Chalcones (1, 3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids,
which are common simple chemical scaffolds found in many naturally occurring compounds …

The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Cancer is a condition caused by many mechanisms (genetic, immune, oxidation, and
inflammatory). Anticancer therapy aims to destroy or stop the growth of cancer cells …

Colorectal cancer (CRC) is a common malignancy with high occurrence and mortality
worldwide. In recent years, the overall survival rate of CRC patients has been improved …

Colorectal cancer (CRC) is one of the most common carcinomas. Although great progress
has been made in recent years, CRC survival remains unsatisfactory due to high metastasis …

Colorectal (CRC) and gastric cancers (GC) are the most common digestive tract cancers
with a high incidence rate worldwide. The current treatment including surgery …

Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

ABSTRACT β-catenin is an evolutionary conserved, quintessential, multifaceted protein that
plays vital roles in cellular homeostasis, embryonic development, organogenesis, stem cell …

Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …