Microsatellite instability (MSI) is a hypermutable phenotype caused by the loss of DNA
mismatch repair activity. MSI is detected in about 15% of all colorectal cancers; 3% are of …

A large body of evidence supports the idea that accumution of mutant APC alleles in affected
kindreds (Groden lated genetic changes underlie the development of neoet al., 1991; …

Whether and how human tumours are genetically unstable has been debated for decades.
There is now evidence that most cancers may indeed be genetically unstable, but that the …

SPONTANEOUS errors in DNA replication have been suggested to play a significant role in
neoplastic transformation and to explain the chromosomal alterations seen in cancer cells1 …

A predisposition to colorectal cancer is shown to be linked to markers on chromosome 2 in
some families. Molecular features of" familial" cancers were compared with those of sporadic …

Recent studies have shown that a locus responsible for hereditary nonpolyposis colorectal
cancer (HNPCC) is on chromosome 2p and that tumors develo** in these patients contain …

HEREDITARY nonpolyposis colorectal cancer (HNPCC) is one of man's commonest
hereditary diseases1. Several studies have implicated a defect in DNA mismatch repair in …

Background Turcot's syndrome is characterized clinically by the concurrence of a primary
brain tumor and multiple colorectal adenomas. We attempted to define the syndrome at the …

Recent data on DNA sequencing of human tumours have established that cancer cells
contain thousands of mutations. These data support the concept that cancer cells express a …

We have proposed that an early step in tumor progression is the expression of a mutator
phenotype resulting from mutations in genes that normally function in the maintenance of …