Inherited cardiac arrhythmias

PJ Schwartz, MJ Ackerman, C Antzelevitch… - Nature reviews Disease …, 2020 - nature.com
The main inherited cardiac arrhythmias are long QT syndrome, short QT syndrome,
catecholaminergic polymorphic ventricular tachycardia and Brugada syndrome. These rare …

J-Wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge

C Antzelevitch, GX Yan, MJ Ackerman, M Borggrefe… - Europace, 2017 - academic.oup.com
The J-wave syndromes (JWSs), consisting of the Brugada syndrome (BrS) and early
repolarization syndrome (ERS), have captured the interest of the cardiology community over …

Role of the autonomic nervous system in modulating cardiac arrhythmias

MJ Shen, DP Zipes - Circulation research, 2014 - Am Heart Assoc
The autonomic nervous system plays an important role in the modulation of cardiac
electrophysiology and arrhythmogenesis. Decades of research has contributed to a better …

Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation

T O'Hara, L Virág, A Varró, Y Rudy - PLoS computational biology, 2011 - journals.plos.org
Cellular electrophysiology experiments, important for understanding cardiac arrhythmia
mechanisms, are usually performed with channels expressed in non myocytes, or with non …

[HTML][HTML] hERG K+ channels: structure, function, and clinical significance

JI Vandenberg, MD Perry, MJ Perrin… - Physiological …, 2012 - journals.physiology.org
The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

Q Chen, GE Kirsch, D Zhang, R Brugada, J Brugada… - Nature, 1998 - nature.com
Ventricular fibrillation causes more than 300, 000 sudden deaths each year in the USA
alone,. In approximately 5–12% of these cases, there are no demonstrable cardiac or non …

[HTML][HTML] Long-term outcome associated with early repolarization on electrocardiography

JT Tikkanen, O Anttonen, MJ Junttila… - … England Journal of …, 2009 - Mass Medical Soc
Background Early repolarization, which is characterized by an elevation of the QRS–ST
junction (J point) in leads other than V1 through V3 on 12-lead electrocardiography, has …

Overview of basic mechanisms of cardiac arrhythmia

C Antzelevitch, A Burashnikov - Cardiac …, 2011 - cardiacep.theclinics.com
A cardiac arrhythmia simply defined is a variation from the normal heart rate and/or rhythm
that is not physiologically justified. Recent years have witnessed important advances in our …

Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome

GX Yan, C Antzelevitch - Circulation, 1998 - Am Heart Assoc
Background—This study probes the cellular basis for the T wave under baseline and long-
QT (LQT) conditions using an arterially perfused canine left ventricular (LV) wedge …

J wave syndromes

C Antzelevitch, GX Yan - Heart rhythm, 2010 - Elsevier
The J wave, also referred to as an Osborn wave, is a deflection immediately following the
QRS complex of the surface ECG. When partially buried in the R wave, the J wave appears …