Towards enabling a cardiovascular digital twin for human systemic circulation using inverse analysis

NK Chakshu, I Sazonov, P Nithiarasu - Biomechanics and modeling in …, 2021 - Springer
An exponential rise in patient data provides an excellent opportunity to improve the existing
health care infrastructure. In the present work, a method to enable cardiovascular digital twin …

Modeling reactive hyperemia to Better Understand and assess microvascular function: a review of techniques

A Coccarelli, MD Nelson - Annals of Biomedical Engineering, 2023 - Springer
Reactive hyperemia is a well-established technique for the non-invasive evaluation of the
peripheral microcirculatory function, measured as the magnitude of limb re-perfusion after a …

A semi‐active human digital twin model for detecting severity of carotid stenoses from head vibration—A coupled computational mechanics and computer vision …

NK Chakshu, J Carson, I Sazonov… - … journal for numerical …, 2019 - Wiley Online Library
In this work, we propose a methodology to detect the severity of carotid stenosis from a video
of a human face with the help of a coupled blood flow and head vibration model. This semi …

Development of non-invasive biomarkers for pre-eclampsia through data-driven cardiovascular network models

C Popp, JM Carson, AB Drysdale, H Arora… - Scientific Reports, 2024 - nature.com
Computational models can be at the basis of new powerful technologies for studying and
classifying disorders like pre-eclampsia, where it is difficult to distinguish pre-eclamptic …

Non‐invasive coronary CT angiography‐derived fractional flow reserve: a benchmark study comparing the diagnostic performance of four different computational …

JM Carson, S Pant, C Roobottom… - … journal for numerical …, 2019 - Wiley Online Library
Non‐invasive coronary computed tomography (CT) angiography‐derived fractional flow
reserve (cFFR) is an emergent approach to determine the functional relevance of obstructive …

First blood: An efficient, hybrid one‐and zero‐dimensional, modular hemodynamic solver

R Wéber, D Gyürki, G Paál - International Journal for Numerical …, 2023 - Wiley Online Library
Abstract Low‐dimensional (1D or 0D) models can describe the whole human blood
circulation, for example, 1D distributed parameter model for the arterial network and 0D …

[HTML][HTML] A semi-implicit finite volume scheme for blood flow in elastic and viscoelastic vessels

A Lucca, S Busto, LO Müller, EF Toro… - Journal of Computational …, 2023 - Elsevier
A novel staggered semi-implicit finite volume method for the simulation of one-dimensional
blood flow in networks of elastic and viscoelastic vessels is proposed. The one-dimensional …

Computational instantaneous wave‐free ratio (IFR) for patient‐specific coronary artery stenoses using 1D network models

JM Carson, C Roobottom, R Alcock… - … Journal for Numerical …, 2019 - Wiley Online Library
In this work, we estimate the diagnostic threshold of the instantaneous wave‐free ratio (iFR)
through the use of a one‐dimensional haemodynamic framework. To this end, we first …

Artificial intelligence approaches to predict coronary stenosis severity using non-invasive fractional flow reserve

JM Carson, NK Chakshu, I Sazonov… - Proceedings of the …, 2020 - journals.sagepub.com
Fractional flow reserve is the current reference standard in the assessment of the functional
impact of a stenosis in coronary heart disease. In this study, three models of artificial …

Influence of ageing on human body blood flow and heat transfer: a detailed computational modelling study

A Coccarelli, HM Hasan, J Carson… - … journal for numerical …, 2018 - Wiley Online Library
Ageing plays a fundamental role in arterial blood transport and heat transfer within a human
body. The aim of this work is to provide a comprehensive methodology, based on …