The biology and functional importance of MAIT cells
DI Godfrey, HF Koay, J McCluskey, NA Gherardin - Nature immunology, 2019 - nature.com
In recent years, a population of unconventional T cells called 'mucosal-associated invariant
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T cells'(MAIT cells) has captured the attention of immunologists and clinicians due to their …
T-cell exhaustion in chronic infections: reversing the state of exhaustion and reinvigorating optimal protective immune responses
T-cell exhaustion is a phenomenon of dysfunction or physical elimination of antigen-specific
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
T cells reported in human immunodeficiency virus (HIV), hepatitis B virus (HBV), and …
Human blood MAIT cell subsets defined using MR1 tetramers
NA Gherardin, MNT Souter, HF Koay… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal‐associated invariant T (MAIT) cells represent up to 10% of circulating human T
cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) …
cells. They are usually defined using combinations of non‐lineage‐specific (surrogate) …
MAIT cells: new guardians of the liver
A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …
Innate immunity of the lung: from basic mechanisms to translational medicine
The respiratory tract is faced daily with 10,000 L of inhaled air. While the majority of air
contains harmless environmental components, the pulmonary immune system also has to …
contains harmless environmental components, the pulmonary immune system also has to …
MAIT cells and viruses
JE Ussher, CB Willberg… - Immunology and cell …, 2018 - Wiley Online Library
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that
specifically targets microbially derived metabolites. Functionally, they respond to bacteria …
specifically targets microbially derived metabolites. Functionally, they respond to bacteria …
[HTML][HTML] Anti-PD-1/PD-L1 therapy for infectious diseases: learning from the cancer paradigm
Objectives Immune checkpoint pathways regulate optimal host immune responses against
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …
transformed cells, induce immunological memory, and limit tissue pathology. Conversely …
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated …
Mucosal-associated invariant T (MAIT) cells, defined as CD161++ TCR iVα7. 2+ T cells, play
an important role in the innate defense against bacterial infections, and their functionality is …
an important role in the innate defense against bacterial infections, and their functionality is …
Peptide-based and small synthetic molecule inhibitors on PD-1/PD-L1 pathway: A new choice for immunotherapy?
T Chen, Q Li, Z Liu, Y Chen, F Feng, H Sun - European journal of medicinal …, 2019 - Elsevier
Blockade the interaction of the programmed cell death protein 1 (PD-1) and its ligand,
programmed death-ligand 1 (PD-L1) can prevent immune evasion of tumor cells and …
programmed death-ligand 1 (PD-L1) can prevent immune evasion of tumor cells and …
[HTML][HTML] Single-cell transcriptional profiling reveals signatures of helper, effector, and regulatory MAIT cells during homeostasis and activation
Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that recognize
microbial vitamin B metabolites and have emerging roles in infectious disease …
microbial vitamin B metabolites and have emerging roles in infectious disease …