IBD disease-modifying therapies: insights from emerging therapeutics

NG Kotla, Y Rochev - Trends in Molecular Medicine, 2023 - cell.com
Inflammatory bowel disease (IBD) pathogenesis is associated with gut mucosal
inflammation, epithelial damage, and dysbiosis leading to a dysregulated gut mucosal …

Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease

D Li, M Yang, H Xu, M Zhu, Y Zhang, C Tian… - Journal of Materials …, 2022 - pubs.rsc.org
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel
disease (IBD) is characterized by recurrent intestinal mucosal inflammation. Oral …

Hyaluronic acid‐based Bioconjugate systems, Scaffolds, and their therapeutic potential

NG Kotla, IL Mohd Isa, A Larrañaga… - Advanced …, 2023 - Wiley Online Library
In recent years, the development of hyaluronic acid or hyaluronan (HA) based scaffolds,
medical devices, bioconjugate systems have expanded into a broad range of research and …

[HTML][HTML] Recent advances and prospects of hyaluronan as a multifunctional therapeutic system

NG Kotla, SR Bonam, S Rasala, J Wankar… - Journal of Controlled …, 2021 - Elsevier
Hyaluronan (HA) is a naturally occurring non-sulfated glycosaminoglycan (GAG), cell-
surface-associated biopolymer and is the key component of tissue extracellular matrix …

Advances in the treatment of inflammatory bowel disease: Focus on polysaccharide nanoparticulate drug delivery systems

H Hadji, K Bouchemal - Advanced Drug Delivery Reviews, 2022 - Elsevier
The complex pathogenesis of inflammatory bowel disease (IBD) explains the several
hurdles for finding an efficient approach to cure it. Nowadays, therapeutic protocols aim to …

[HTML][HTML] Inflammation-specific targeted carriers for local drug delivery to inflammatory bowel disease

NG Kotla, R Singh, BV Baby, S Rasala, J Rasool… - Biomaterials, 2022 - Elsevier
Delivering drugs directly to the inflamed intestinal sites to treat inflammatory bowel disease
(IBD), particularly Crohn's and ulcerative colitis, is highly challenging. Recent advances in …

Modulation of gut barrier functions in ulcerative colitis by hyaluronic acid system

NG Kotla, ILM Isa, S Rasala, S Demir… - Advanced …, 2022 - Wiley Online Library
The active stages of intestinal inflammation and the pathogenesis of ulcerative colitis are
associated with superficial mucosal damage and intermittent wounding that leads to …

[HTML][HTML] Novel drug delivery systems for inflammatory bowel disease

F Yasmin, H Najeeb, S Shaikh… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD) is a chronic illness characterized by relapsing
inflammation of the intestines. The disorder is stratified according to the severity and is …

Natural product-based nanomedicine in treatment of inflammatory bowel disease

T Khare, SS Palakurthi, BM Shah, S Palakurthi… - International journal of …, 2020 - mdpi.com
Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory
Bowel Disease (IBD). However, they all are implicated in causing severe side effects and …

Colon-targeted delivery systems for nutraceuticals: A review of current vehicles, evaluation methods and future prospects

K Feng, Y Wei, T Hu, RJ Linhardt, M Zong… - Trends in Food Science & …, 2020 - Elsevier
Background Advances in nutriology have suggested the colon as a superior site for nutrition
absorption. Nutraceuticals, including phytochemicals, probiotics, etc., have received great …