The prediction of protein three-dimensional structure from amino acid sequence has been a
grand challenge problem in computational biophysics for decades, owing to its intrinsic …

Recent breakthroughs in AI coupled with the rapid accumulation of protein sequence and
structure data have radically transformed computational protein design. New methods …

Therapeutic antibody development requires selection and engineering of molecules with
high affinity and other drug-like biophysical properties. Co-optimization of multiple antibody …

The CRISPR-Cas9 system has raised hopes for develo** personalized gene therapies for
complex diseases. Its application for genetic and epigenetic therapies in humans raises …

Antibody directed enzyme prodrug therapy has the potential to be an effective therapy for
most common solid cancers. Clinical studies with CPG2 system have shown the feasibility of …

Genome‐editing therapeutics are poised to treat human diseases. As we enter clinical trials
with the most promising CRISPR‐Cas9 and CRISPR‐Cas12a (Cpf1) modalities, the risks …

Synthetic transcription factors (synTFs) that control beneficial transgene expression are an
important method to increase the safety and efficacy of cell and gene therapy. Reliance on …

Biotherapeutics, and antimicrobial proteins in particular, are of increasing interest for human
medicine. An important challenge in the development of such therapeutics is their potential …

Enzymes have been used to direct the conversion of prodrugs in cancer therapy. However,
non‐specific distribution of endogenous enzymes seriously hinders their bioapplications …

There is intense and widespread interest in develo** monoclonal antibodies as
therapeutic agents to treat diverse human disorders. During early-stage antibody discovery …