Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Detailed structural, biochemical, cell biological, and genetic studies of any gene/protein are
required to develop models of its actions in cells. Studying a protein family in the aggregate …

Abstract Background N6‐methyladenosine (m6A) RNA modification has been demonstrated
to be a significant regulatory process in the progression of various tumors, including breast …

Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G)
proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and …

The positioning of lysosomes within the cytoplasm is emerging as a critical determinant of
many lysosomal functions. Here we report the identification of a multisubunit complex …

The BBSome is a complex of Bardet-Biedl Syndrome (BBS) proteins that shares common
structural elements with COPI, COPII, and clathrin coats. Here, we show that the BBSome …

Diabetic nephropathy is a well-known complication of diabetes and is a leading cause of
chronic renal failure in the Western world. It is characterized by the accumulation of …

Abstract Triple-negative (ER−, HER2−, PR−) breast cancer (TNBC) is an aggressive disease
with a poor prognosis with no available molecularly targeted therapy. Silencing of microRNA …

Summary The Rab GTPases recruit peripheral membrane proteins to intracellular
organelles. These Rab effectors typically mediate the motility of organelles and vesicles and …

Stem cells are primitive cells found in many multicellular organisms. Self-renewal and
differentiation potency are two defining properties of stem cells. Self-renewal is the ability to …