Methionine metabolism in health and cancer: a nexus of diet and precision medicine
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …
The intersection of epigenetics and metabolism in trained immunity
The last few years have witnessed an increasing body of evidence that challenges the
traditional view that immunological memory is an exclusive trait of the adaptive immune …
traditional view that immunological memory is an exclusive trait of the adaptive immune …
Metabolic reprogramming and epigenetic modifications on the path to cancer
L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
The impact of cellular metabolism on chromatin dynamics and epigenetics
The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …
Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …
WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data
The emergence of large gene expression datasets has revealed the need for improved tools
to identify enriched gene categories and visualize enrichment patterns. While gene …
to identify enriched gene categories and visualize enrichment patterns. While gene …
Metabolic control of methylation and acetylation
Highlights•Epigenetic methylation and acetylation are sensitive to cellular metabolic
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …
DNA nanotechnology‐based biosensors and therapeutics
Over the past few decades, DNA nanotechnology engenders a vast variety of programmable
nanostructures utilizing Watson–Crick base pairing. Due to their precise engineering …
nanostructures utilizing Watson–Crick base pairing. Due to their precise engineering …
Undercover: gene control by metabolites and metabolic enzymes
JA van der Knaap, CP Verrijzer - Genes & development, 2016 - genesdev.cshlp.org
To make the appropriate developmental decisions or maintain homeostasis, cells and
organisms must coordinate the expression of their genome and metabolic state. However …
organisms must coordinate the expression of their genome and metabolic state. However …
Cul4A-DDB1–mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine
Y Zhang, H Yu, J Zhang, H Gao… - The Journal of …, 2021 - Am Soc Clin Investig
Although serine metabolism plays a crucial role in the proliferation and survival of tumor
cells, how it supports tumor cell migration remains poorly understood. Phosphoglycerate …
cells, how it supports tumor cell migration remains poorly understood. Phosphoglycerate …