Methionine metabolism in health and cancer: a nexus of diet and precision medicine

SM Sanderson, X Gao, Z Dai, JW Locasale - Nature Reviews Cancer, 2019 - nature.com
Methionine uptake and metabolism is involved in a host of cellular functions including
methylation reactions, redox maintenance, polyamine synthesis and coupling to folate …

The intersection of epigenetics and metabolism in trained immunity

S Fanucchi, J Domínguez-Andrés, LAB Joosten… - Immunity, 2021 - cell.com
The last few years have witnessed an increasing body of evidence that challenges the
traditional view that immunological memory is an exclusive trait of the adaptive immune …

Metabolic reprogramming and epigenetic modifications on the path to cancer

L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

The impact of cellular metabolism on chromatin dynamics and epigenetics

MA Reid, Z Dai, JW Locasale - Nature cell biology, 2017 - nature.com
The substrates used to modify nucleic acids and chromatin are affected by nutrient
availability and the activity of metabolic pathways. Thus, cellular metabolism constitutes a …

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

AA Parkhitko, P Jouandin, SE Mohr, N Perrimon - Aging cell, 2019 - Wiley Online Library
Methionine restriction (MetR) extends lifespan across different species and exerts beneficial
effects on metabolic health and inflammatory responses. In contrast, certain cancer cells …

WormCat: An Online Tool for Annotation and Visualization of Caenorhabditis elegans Genome-Scale Data

AD Holdorf, DP Higgins, AC Hart, PR Boag… - Genetics, 2020 - academic.oup.com
The emergence of large gene expression datasets has revealed the need for improved tools
to identify enriched gene categories and visualize enrichment patterns. While gene …

Metabolic control of methylation and acetylation

X Su, KE Wellen, JD Rabinowitz - Current opinion in chemical biology, 2016 - Elsevier
Highlights•Epigenetic methylation and acetylation are sensitive to cellular metabolic
status.•Diet and environment conditions shape epigenetics through metabolism.•Stem cells …

DNA nanotechnology‐based biosensors and therapeutics

L Shen, P Wang, Y Ke - Advanced healthcare materials, 2021 - Wiley Online Library
Over the past few decades, DNA nanotechnology engenders a vast variety of programmable
nanostructures utilizing Watson–Crick base pairing. Due to their precise engineering …

Undercover: gene control by metabolites and metabolic enzymes

JA van der Knaap, CP Verrijzer - Genes & development, 2016 - genesdev.cshlp.org
To make the appropriate developmental decisions or maintain homeostasis, cells and
organisms must coordinate the expression of their genome and metabolic state. However …

Cul4A-DDB1–mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine

Y Zhang, H Yu, J Zhang, H Gao… - The Journal of …, 2021 - Am Soc Clin Investig
Although serine metabolism plays a crucial role in the proliferation and survival of tumor
cells, how it supports tumor cell migration remains poorly understood. Phosphoglycerate …