During skeletal myogenesis, chromatin-modifying enzymes are engaged at discrete
genomic regions by transcription factors that recognize sequence-specific DNA motifs …

MEF2C is a selectively expressed transcription factor involved in different transcriptional
complexes. Originally identified as an essential regulator of muscle development, ectopic …

Although many transcription factors are known to control important aspects of neural
development, the genome-wide programs that are directly regulated by these factors are not …

Transcription factor (TF) regulation is often post-translational. TF modifications such as
reversible phosphorylation and missense mutations, which can act independent of TF …

Background Arsenic exposure impairs development and can lead to cancer, cardiovascular
disease, and diabetes. The mechanism underlying these effects remains unknown. Primarily …

Introduction Bromodomain-containing Protein 4 (BRD4) is a transcriptional regulator which
coordinates gene expression programs controlling cancer biology, inflammation, and …

Differential Display PCR technique (DD-PCR) was used for the analysis of altered gene
expression in hemocytes of Vibrio harveyi-infected Penaeus monodon. Forty-four …

In skeletal muscle cells, the PC4 (Tis7/Ifrd1) protein is known to function as a coactivator of
MyoD by promoting the transcriptional activity of myocyte enhancer factor 2C (MEF2C). In …

The class IIa histone deacetylases (HDACs) act as transcriptional repressors by altering
chromatin structure through histone deacetylation. This family of enzymes regulates muscle …

Selenium deficiency causes further impairment of thyroid hormone metabolism in iodine-
deficient rats and therefore could have a role in the aetiology of both myxoedematous and …