Long-term effects of severe burns on the kidneys: research advances and potential therapeutic approaches

G Yang, L Tan, H Yao, Z **ong, J Wu… - Journal of Inflammation …, 2023 - Taylor & Francis
Burns are a seriously underestimated form of trauma that not only damage the skin system
but also cause various complications, such as acute kidney injury (AKI). Recent clinical …

Several alkaloids in Chinese herbal medicine exert protection in acute kidney injury: focus on mechanism and target analysis

Y Rui, S Li, F Luan, D Li, R Liu… - Oxidative medicine and …, 2022 - Wiley Online Library
Objectives. Acute kidney injury (AKI) is a loose set of kidney diseases accompanied by a
variety of syndromes, which is a serious threat to human life and health. Some alkaloids are …

1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid–Bilirubin …

Y Wang, M Pu, J Yan, J Zhang, H Wei, L Yu, X Yan… - ACS …, 2022 - ACS Publications
Calcium overload is one of the early determinants of the core cellular events that contribute
to the pathogenesis of acute kidney injury (AKI), which include oxidative stress, ATP …

Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment‐Responsive BAPTA‐AM/BAC Co …

J Yan, Y Wang, J Zhang, X Liu, L Yu, Z He - Small, 2023 - Wiley Online Library
Calcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI),
are self‐amplifying and mutually reinforcing, forming a complicated cascading feedback …

BMAL1 regulates mitochondrial homeostasis in renal ischaemia‐reperfusion injury by mediating the SIRT1/PGC‐1α axis

P Ye, W Li, X Huang, S Zhao, W Chen… - Journal of cellular …, 2022 - Wiley Online Library
The regulation of renal function by circadian gene BMAL1 has been recently recognized;
however, the role and mechanism of BMAL1 in renal ischaemia‐reperfusion injury (IRI) are …

CIRBP promotes ferroptosis by interacting with ELAVL1 and activating ferritinophagy during renal ischaemia‐reperfusion injury

M Sui, D Xu, W Zhao, H Lu, R Chen… - Journal of Cellular …, 2021 - Wiley Online Library
Renal ischaemia‐reperfusion (IR) is a major cause of acute kidney injury (AKI). Cold‐
inducible RNA‐binding protein (CIRBP) may contribute to AKI because its deficiency …

Tissue culture models of AKI: from tubule cells to human kidney organoids

J Bejoy, ES Qian, LE Woodard - Journal of the American Society of …, 2022 - journals.lww.com
AKI affects approximately 13.3 million people around the world each year, causing CKD
and/or mortality. The mammalian kidney cannot generate new nephrons after postnatal …

Renal microcirculation injury as the main cause of ischemic acute kidney injury development

E Kwiatkowska, S Kwiatkowski, V Dziedziejko… - Biology, 2023 - mdpi.com
Simple Summary Acute kidney injury can result from multiple factors. The main cause is
reduced renal perfusion. Kidneys are susceptible to ischemia due to the anatomy of …

Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1

D Yang, Y Fan, M **ong, Y Chen, Y Zhou, X Liu… - EMBO …, 2023 - embopress.org
Surgery‐induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like
cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid …

Neutrophil‐Mediated Nanozyme Delivery System for Acute Kidney Injury Therapy

Y Yang, J Du, J Gan, X Song, J Shu… - Advanced …, 2024 - Wiley Online Library
Reactive oxygen species (ROS) scavenging of nanozymes toward acute kidney injury (AKI)
is a current promising strategy, however, the glomerular filtration barrier (GFB) limits their …