[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics
Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …
Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …
It provides protection and acts as a barrier against external menaces like allergens …
[HTML][HTML] Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses
Pharmaceutical analysis is a discipline based on chemical, physical, biological, and
information technologies. At present, biotechnological analysis is a short branch in …
information technologies. At present, biotechnological analysis is a short branch in …
Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy
X Peng, W Pan, F Jiang, W Chen, Z Qi, W Peng… - Pharmacological …, 2022 - Elsevier
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …
[HTML][HTML] CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer
T Deng, P Shen, A Li, Z Zhang, H Yang, X Deng… - Theranostics, 2021 - ncbi.nlm.nih.gov
The coiled-coil domain containing protein members have been well documented for their
roles in many diseases including cancers. However, the function of the coiled-coil domain …
roles in many diseases including cancers. However, the function of the coiled-coil domain …
Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions
The rising trend of gastrointestinal (GI) cancer has become a global burden due to its
aggressive nature and poor prognosis. Long noncoding RNAs (lncRNAs) have recently …
aggressive nature and poor prognosis. Long noncoding RNAs (lncRNAs) have recently …
Targeting fibrosis: The bridge that connects pancreatitis and pancreatic cancer
C Huang, J Iovanna, P Santofimia-Castaño - International Journal of …, 2021 - mdpi.com
Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …
Resveratrol and tumor microenvironment: Mechanistic basis and therapeutic targets
Resveratrol (3, 4′, 5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It
has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory …
has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory …
Molecular regulatory roles of long non-coding RNA HOTTIP: an overview in gastrointestinal cancers
Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases
worldwide and are highly characterised by poor prognosis. The poor overall survival is …
worldwide and are highly characterised by poor prognosis. The poor overall survival is …
Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis
L Qi, H Han, MM Han, Y Sun, L **ng, HL Jiang… - Biomaterials, 2023 - Elsevier
Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM)
homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic …
homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic …