[HTML][HTML] New opportunities and challenges of natural products research: When target identification meets single-cell multiomics

Y Zhu, Z Ouyang, H Du, M Wang, J Wang, H Sun… - … Pharmaceutica Sinica B, 2022 - Elsevier
Natural products, and especially the active ingredients found in traditional Chinese medicine
(TCM), have a thousand-year-long history of clinical use and a strong theoretical basis in …

Promising natural products in new drug design, development, and therapy for skin disorders: An overview of scientific evidence and understanding their mechanism of …

NA Mohd Zaid, M Sekar, SR Bonam… - Drug design …, 2023 - Taylor & Francis
The skin is the largest organ in the human body, composed of the epidermis and the dermis.
It provides protection and acts as a barrier against external menaces like allergens …

[HTML][HTML] Emerging biotechnology applications in natural product and synthetic pharmaceutical analyses

S Chen, Z Li, S Zhang, Y Zhou, X **ao, P Cui… - … Pharmaceutica Sinica B, 2022 - Elsevier
Pharmaceutical analysis is a discipline based on chemical, physical, biological, and
information technologies. At present, biotechnological analysis is a short branch in …

Selective PARP1 inhibitors, PARP1-based dual-target inhibitors, PROTAC PARP1 degraders, and prodrugs of PARP1 inhibitors for cancer therapy

X Peng, W Pan, F Jiang, W Chen, Z Qi, W Peng… - Pharmacological …, 2022 - Elsevier
Poly ADP-ribose polymerase (PARP) plays a critical role in many cellular processes such as
DNA damage repair, gene transcription and cell apoptosis. Therefore, targeting PARP …

[HTML][HTML] CCDC65 as a new potential tumor suppressor induced by metformin inhibits activation of AKT1 via ubiquitination of ENO1 in gastric cancer

T Deng, P Shen, A Li, Z Zhang, H Yang, X Deng… - Theranostics, 2021 - ncbi.nlm.nih.gov
The coiled-coil domain containing protein members have been well documented for their
roles in many diseases including cancers. However, the function of the coiled-coil domain …

Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions

S Ramli, MS Sim, RM Guad, SCB Gopinath… - Journal of …, 2021 - Wiley Online Library
The rising trend of gastrointestinal (GI) cancer has become a global burden due to its
aggressive nature and poor prognosis. Long noncoding RNAs (lncRNAs) have recently …

Targeting fibrosis: The bridge that connects pancreatitis and pancreatic cancer

C Huang, J Iovanna, P Santofimia-Castaño - International Journal of …, 2021 - mdpi.com
Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …

Resveratrol and tumor microenvironment: Mechanistic basis and therapeutic targets

WH Talib, AR Alsayed, F Farhan, LT Al Kury - Molecules, 2020 - mdpi.com
Resveratrol (3, 4′, 5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It
has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory …

Molecular regulatory roles of long non-coding RNA HOTTIP: an overview in gastrointestinal cancers

UZ Hamid, MS Sim, RM Guad… - Current molecular …, 2022 - ingentaconnect.com
Gastrointestinal (GI) cancers presented an alarmingly high number of new cancer cases
worldwide and are highly characterised by poor prognosis. The poor overall survival is …

Remodeling of imbalanced extracellular matrix homeostasis for reversal of pancreatic fibrosis

L Qi, H Han, MM Han, Y Sun, L **ng, HL Jiang… - Biomaterials, 2023 - Elsevier
Pancreatic fibrosis is mainly manifested by imbalance in extracellular matrix (ECM)
homeostasis due to excessive deposition of collagen in pancreas by activated pancreatic …