Phase transitions of associative biomacromolecules
Multivalent proteins and nucleic acids, collectively referred to as multivalent associative
biomacromolecules, provide the driving forces for the formation and compositional …
biomacromolecules, provide the driving forces for the formation and compositional …
The molecular basis for cellular function of intrinsically disordered protein regions
Intrinsically disordered protein regions exist in a collection of dynamic interconverting
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
conformations that lack a stable 3D structure. These regions are structurally heterogeneous …
[HTML][HTML] Phase separation of FSP1 promotes ferroptosis
Ferroptosis is evolving as a highly promising approach to combat difficult-to-treat tumour
entities including therapy-refractory and dedifferentiating cancers,–. Recently, ferroptosis …
entities including therapy-refractory and dedifferentiating cancers,–. Recently, ferroptosis …
Cellular functions of eukaryotic RNA helicases and their links to human diseases
RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …
Emerging roles and functional mechanisms of PIWI-interacting RNAs
X Wang, A Ramat, M Simonelig, MF Liu - Nature Reviews Molecular …, 2023 - nature.com
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
The SARS-CoV-2 nucleocapsid protein: its role in the viral life cycle, structure and functions, and use as a potential target in the development of vaccines and …
W Wu, Y Cheng, H Zhou, C Sun, S Zhang - Virology journal, 2023 - Springer
Abstract Coronavirus disease 2019 (COVID-19) continues to take a heavy toll on personal
health, healthcare systems, and economies around the globe. Scientists are expending …
health, healthcare systems, and economies around the globe. Scientists are expending …
Biomimetic peptide self-assembly for functional materials
Natural biomolecular systems have evolved to form a rich variety of supramolecular
materials and machinery fundamental to cellular function. The assembly of these structures …
materials and machinery fundamental to cellular function. The assembly of these structures …
Plant abiotic stress response and nutrient use efficiency
Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce
plant growth, productivity and quality. Plants have evolved mechanisms to perceive these …
plant growth, productivity and quality. Plants have evolved mechanisms to perceive these …
Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity
Patients with Coronavirus disease 2019 exhibit low expression of interferon-stimulated
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
genes, contributing to a limited antiviral response. Uncovering the underlying mechanism of …
MobiDB: 10 years of intrinsically disordered proteins
The MobiDB database (URL: https://mobidb. org/) is a knowledge base of intrinsically
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …