Metabolomics in diabetes and diabetic complications: insights from epidemiological studies

Q **, RCW Ma - Cells, 2021 - mdpi.com
The increasing prevalence of diabetes and its complications, such as cardiovascular and
kidney disease, remains a huge burden globally. Identification of biomarkers for the …

The impact of aerobic exercise on HDL quantity and quality: a narrative review

B Franczyk, A Gluba-Brzózka… - International journal of …, 2023 - mdpi.com
High-density lipoproteins comprise roughly 25–30% of the circulating proteins involved in
the transport of lipids in circulation. These particles differ in size and lipid composition …

Randomised clinical trial: pemafibrate, a novel selective peroxisome proliferator‐activated receptor α modulator (SPPARMα), versus placebo in patients with non …

A Nakajima, Y Eguchi, M Yoneda… - Alimentary …, 2021 - Wiley Online Library
Background Pemafibrate is a novel, selective peroxisome proliferator‐activated receptor α
modulator (SPPARMα). In mice, Pemafibrate improved the histological features of non …

Dysfunctional HDL and atherosclerotic cardiovascular disease

RS Rosenson, HB Brewer Jr, BJ Ansell… - Nature reviews …, 2016 - nature.com
High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease

P Zanoni, SA Khetarpal, DB Larach… - Science, 2016 - science.org
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a …

Relationship between gut microbiota and circulating metabolites in population-based cohorts

D Vo**ovic, D Radjabzadeh, A Kurilshikov… - Nature …, 2019 - nature.com
Gut microbiota has been implicated in major diseases affecting the human population and
has also been linked to triglycerides and high-density lipoprotein levels in the circulation …

High-density lipoprotein anti-inflammatory capacity and incident cardiovascular events

C Jia, JLC Anderson, EG Gruppen, Y Lei, SJL Bakker… - Circulation, 2021 - ahajournals.org
Background: The role of high-density lipoprotein (HDL) function in cardiovascular disease
represents an important emerging concept. The present study investigated whether HDL anti …

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

PJ Meikle, SA Summers - Nature Reviews Endocrinology, 2017 - nature.com
Obesity, insulin resistance, type 2 diabetes mellitus and cardiovascular disease form a
metabolic disease continuum that has seen a dramatic increase in prevalence in developed …

Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

T Cajka, O Fiehn - TrAC Trends in Analytical Chemistry, 2014 - Elsevier
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

[HTML][HTML] Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit

F Brites, M Martin, I Guillas, A Kontush - BBA clinical, 2017 - Elsevier
Uptake of low-density lipoprotein (LDL) particles by macrophages represents a key step in
the development of atherosclerotic plaques, leading to the foam cell formation. Chemical …