Although the roots of Ras sprouted from the rich history of retrovirus research, it was the
discovery of mutationally activated RAS genes in human cancer in 1982 that stimulated an …

Growth and proliferation of microorganisms such as the yeast Saccharomyces cerevisiae
are controlled in part by the availability of nutrients. When proliferating yeast cells exhaust …

1FlyBase (http://www. flybase. bio. indiana. edu). 2Berkeley Drosophila Genome Project
(http://fruitfly. bdgp. berkeley. edu). 3Saccharomyces Genome Database (http://genome …

Genomic sequencing has made it clear that a large fraction of the genes specifying the core
biological functions are shared by all eukaryotes. Knowledge of the biological role of such …

The first complete DNA sequence of a eukaryotic genome, that of the yeast Saccharomyces
cerevisiae, was released in electronic form more than a year ago (1). No doubt, each …

We have identified proteins that interact with H-Ras using a two hybrid system screen of a
mouse cDNA library. Approximately 50% of the clones identified encoded portionsof the c …

Yeast and cancer cells share the unusual characteristic of favoring fermentation of sugar
over respiration. We now reveal an evolutionary conserved mechanism linking fermentation …

We developed a method for immunoaffinity purification of Saccharomyces cerevisiae
adenylyl cyclase based on creating a fusion with a small peptide epitope. Using …

We continue to lose species and genetic diversity locally, nationally, and planet-wide. In
deciding priorities for conservation, there is an urgent need for criteria that help us to …

This article reviews the origin and evolution of high throughput screening (HTS) through the
experience of an individual pharmaceutical company, revealing some of the mysteries of the …