Acute myeloid leukemia (AML) is a heterogeneous clonal disorder characterized by
immature myeloid cell proliferation and bone marrow failure. Cytogenetics and mutation …

Molecular analyses of leukemic blasts from patients with acute myeloid leukemia (AML)
have revealed a striking heterogeneity with regard to the presence of acquired gene …

The CEBPA gene is mutated in 9% of patients with acute myeloid leukemia (AML). Selective
expression of a short (30-kDa) CCAAT-enhancer binding protein-α (C/EBPα) translational …

Purpose To study the incidence and prognostic impact of mutations in DNA
methyltransferase 3A (DNMT3A) in patients with acute myeloid leukemia. Patients and …

The C/EBP family of proteins represents an important group of bZIP transcription factors that
are key to the regulation of essential functions such as cell cycle, hematopoiesis, skeletal …

The polycomb repressive complex (PRC) 2 contains 3 core proteins, EZH2, SUZ12, and
EED, in which the SET (suppressor of variegation–enhancer of zeste-trithorax) domain of …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

The molecular analysis of biomarkers in oncology is rapidly advancing, but the incorporation
of new molecular tests into clinical practice will require a greater understanding of the …

Context.—A complete diagnosis of acute leukemia requires knowledge of clinical
information combined with morphologic evaluation, immunophenoty** and karyotype …

Granulocyte colony-stimulating factor (G-CSF) mediates “emergency” granulopoiesis during
infection, a process that is mimicked by clinical G-CSF use, yet we understand little about the …