Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Telomerase is the essential reverse transcriptase required for linear chromosome
maintenance in most eukaryotes. Telomerase supplements the tandem array of simple …

The lengths of human telomeres, which protect chromosome ends from degradation and
end fusions,, are crucial determinants of cell lifespan. During embryogenesis and in cancer …

Elongation of a short telomere depends on the action of multiple telomerase molecules,
which are visible as telomerase RNA foci or clusters associated with telomeres in yeast and …

Chromosome end protection is essential to protect genome integrity. Telomeres, tracts of
repetitive DNA sequence and associated proteins located at the chromosomal terminus …

Telomerase maintains genome integrity by adding repetitive DNA sequences to the
chromosome ends in actively dividing cells, including 90% of all cancer cells. Recruitment of …

Telomerase is the ribonucleoprotein (RNP) enzyme that elongates telomeric DNA to
compensate for the attrition occurring during each cycle of DNA replication. Knowing the …

It has become increasingly apparent that gene expression is regulated by the functional
interplay between spatial genome organization and nuclear architecture. Within the nuclear …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

Telomeres are the physical ends of eukaryotic chromosomes. They protect chromosome
ends from DNA degradation, recombination, and DNA end fusions, and they are important …