Fetal metabolic programming caused by the adverse intrauterine environment can induce
metabolic syndrome in adult offspring. Adverse intrauterine environment introduces fetal …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Exposure to environmental factors in early life can influence developmental processes and
long-term health in humans. Early life nutrition and maternal diet are well-known examples …

Pancreatic β cells differentiate during fetal life, but only postnatally acquire the capacity for
glucose-stimulated insulin secretion (GSIS). How this happens is not clear. In exploring what …

Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of
key processes in cell biology, including development, differentiation, and survival. Currently …

The importance of sexual dimorphism has been highlighted in recent years since the
National Institutes of Health's mandate on considering sex as a biological variable. Although …