RNA modifications: importance in immune cell biology and related diseases

L Cui, R Ma, J Cai, C Guo, Z Chen, L Yao… - Signal transduction and …, 2022 - nature.com
RNA modifications have become hot topics recently. By influencing RNA processes,
including generation, transportation, function, and metabolization, they act as critical …

N6-methyladenosine RNA modification in inflammation: roles, mechanisms, and applications

J Luo, T Xu, K Sun - Frontiers in cell and developmental biology, 2021 - frontiersin.org
N6-methyladenosine (m6A) is the most prevalent internal mRNA modification. m6A can be
installed by the methyltransferase complex and removed by demethylases, which are …

EWAS Atlas: a curated knowledgebase of epigenome-wide association studies

M Li, D Zou, Z Li, R Gao, J Sang, Y Zhang… - Nucleic acids …, 2019 - academic.oup.com
Abstract Epigenome-Wide Association Study (EWAS) has become increasingly significant in
identifying the associations between epigenetic variations and different biological traits. In …

New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

H Xu, S Lin, Z Zhou, D Li, X Zhang, M Yu… - Cellular & Molecular …, 2023 - nature.com
Over the past thirty years, the importance of chemokines and their seven-transmembrane G
protein-coupled receptors (GPCRs) has been increasingly recognized. Chemokine …

The component of the m6A writer complex VIRMA is implicated in aggressive tumor phenotype, DNA damage response and cisplatin resistance in germ cell tumors

V Miranda-Gonçalves, J Lobo… - Journal of Experimental …, 2021 - Springer
Abstract Background Germ cell tumors (GCTs) are developmental cancers, tightly linked to
embryogenesis and germ cell development. The recent and expanding field of RNA …

Melatonin: regulation of biomolecular condensates in neurodegenerative disorders

D Loh, RJ Reiter - Antioxidants, 2021 - mdpi.com
Biomolecular condensates are membraneless organelles (MLOs) that form dynamic,
chemically distinct subcellular compartments organizing macromolecules such as proteins …

[HTML][HTML] Advances in the toxicology research of microcystins based on Omics approaches

Y Ma, H Liu, X Du, Z Shi, X Liu, R Wang, S Zhang… - Environment …, 2021 - Elsevier
Microcystins (MCs) are the most widely distributed cyanotoxins, which can be ingested by
animals and human body in multiple ways, resulting in a threat to human health and the …

The emerging role of epitranscriptomics in cancer: focus on urological tumors

J Lobo, D Barros-Silva, R Henrique, C Jerónimo - Genes, 2018 - mdpi.com
Epitranscriptomics has gained ground in recent years, especially after the advent of
techniques for accurately studying these mechanisms. Among all modifications occurring in …

The current and emerging Klotho-enhancement strategies

H Poursistany, ST Azar, MT Azar, S Raeisi - Biochemical and Biophysical …, 2024 - Elsevier
Klotho is well known as a gene with antiaging properties. It has membrane and soluble
forms, providing a unique system that controls various metabolic processes essential to …

Melatonin: Regulation of viral phase separation and Epitranscriptomics in post-acute sequelae of COVID-19

D Loh, RJ Reiter - International journal of molecular sciences, 2022 - mdpi.com
The relentless, protracted evolution of the SARS-CoV-2 virus imposes tremendous pressure
on herd immunity and demands versatile adaptations by the human host genome to counter …