Cell culture in microfluidic droplets

S Sart, G Ronteix, S Jain, G Amselem… - Chemical …, 2022 - ACS Publications
Cell manipulation in droplets has emerged as one of the great successes of microfluidic
technologies, with the development of single-cell screening. However, the droplet format has …

[HTML][HTML] Application of microfluidic chip technology in pharmaceutical analysis: A review

P Cui, S Wang - Journal of pharmaceutical analysis, 2019 - Elsevier
The development of pharmaceutical analytical methods represents one of the most
significant aspects of drug development. Recent advances in microfabrication and …

The Poisson distribution and beyond: methods for microfluidic droplet production and single cell encapsulation

DJ Collins, A Neild, A DeMello, AQ Liu, Y Ai - Lab on a Chip, 2015 - pubs.rsc.org
There is a recognized and growing need for rapid and efficient cell assays, where the size of
microfluidic devices lend themselves to the manipulation of cellular populations down to the …

Microfluidics for cell-based high throughput screening platforms—A review

G Du, Q Fang, JMJ den Toonder - Analytica chimica acta, 2016 - Elsevier
In the last decades, the basic techniques of microfluidics for the study of cells such as cell
culture, cell separation, and cell lysis, have been well developed. Based on cell handling …

Multiphase flow in microfluidics: From droplets and bubbles to the encapsulated structures

A Sattari, P Hanafizadeh, M Hoorfar - Advances in Colloid and Interface …, 2020 - Elsevier
Microfluidic technologies have a unique ability to control more precisely and effectively on
two-phase flow systems in comparison with macro systems. Controlling the size of the …

[HTML][HTML] Modelling of compound combination effects and applications to efficacy and toxicity: state-of-the-art, challenges and perspectives

KC Bulusu, R Guha, DJ Mason, RPI Lewis… - Drug discovery today, 2016 - Elsevier
Highlights•Review of the state-of-the-art in the field of compound combination modelling.•
Significance of quality control of large-scale combination screening data.•Strategies for …

Recent advances in applications of droplet microfluidics

WL Chou, PY Lee, CL Yang, WY Huang, YS Lin - Micromachines, 2015 - mdpi.com
Droplet-based microfluidics is a colloidal and interfacial system that has rapidly progressed
in the past decade because of the advantages of low fabrication costs, small sample …

Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment

BL Khoo, G Grenci, T **g, YB Lim, SC Lee… - Science …, 2016 - science.org
The lack of a robust anticancer drug screening system to monitor patients during treatment
delays realization of personalized treatment. We demonstrate an efficient approach to …

Sessile droplets for chemical and biological assays

JL Garcia-Cordero, ZH Fan - Lab on a Chip, 2017 - pubs.rsc.org
Sessile droplets are non-movable droplets spanning volumes in the nL-to-μL range. The
sessile-droplet-based platform provides a paradigm shift from the conventional, flow-based …

Recent advances in microfluidics for drug screening

J Sun, AR Warden, X Ding - Biomicrofluidics, 2019 - pubs.aip.org
With ever increasing drug resistance and emergence of new diseases, demand for new drug
development is at an unprecedented urgency. This fact has led to extensive recent efforts to …