The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

N-Methyl-D-aspartate ionotropic glutamate receptors (NMDARs) play key roles in
synaptogenesis, synaptic maturation, long-term plasticity, neuronal network activity, and …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer's disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

Synapses are found in vast numbers in the brain and contain complex proteomes. We
developed genetic labeling and imaging methods to examine synaptic proteins in individual …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

In the life sciences, a new paradigm is emerging that places networks of interacting
molecules between genotype and phenotype. These networks are dynamically modulated …

The nervous system is made of a large number of neurons. Time-varying balance between
excitatory and inhibitory neurons is important to activate appropriate modes of electrical …

Mutations of the cyclin-dependent kinase-like 5 (CDKL5) and netrin-G1 (NTNG1) genes
cause a severe neurodevelopmental disorder with clinical features that are closely related to …

The human synapse proteome is a highly complex collection of proteins that is disrupted by
hundreds of gene mutations causing over 100 brain diseases. These synaptic diseases, or …

Membraneless organelles formed by phase separation of proteins and nucleic acids play
diverse cellular functions. Whether and, if yes, how membraneless organelles in ways …