Multiple sclerosis progression: time for a new mechanism-driven framework
Traditionally, multiple sclerosis has been categorised by distinct clinical descriptors—
relapsing-remitting, secondary progressive, and primary progressive—for patient care …
relapsing-remitting, secondary progressive, and primary progressive—for patient care …
Multiple sclerosis: Neuroimmune crosstalk and therapeutic targeting
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of the central
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
nervous system afflicting nearly three million individuals worldwide. Neuroimmune …
How patients with multiple sclerosis acquire disability
Patients with multiple sclerosis acquire disability either through relapse-associated
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
worsening (RAW) or progression independent of relapse activity (PIRA). This study …
Treatment of multiple sclerosis: a review
Multiple sclerosis (MS) is an autoimmune demyelinating and neurodegenerative disease of
the central nervous system, and the leading cause of nontraumatic neurological disability in …
the central nervous system, and the leading cause of nontraumatic neurological disability in …
Acute clinical events identified as relapses with stable magnetic resonance imaging in multiple sclerosis
Importance Understanding the association between clinically defined relapses and
radiological activity in multiple sclerosis (MS) is essential for patient treatment and …
radiological activity in multiple sclerosis (MS) is essential for patient treatment and …
Secondary progressive multiple sclerosis: new insights
In most cases, multiple sclerosis (MS) begins with a relapsing-remitting course followed by
insidious disability worsening that is independent from clinically apparent relapses and is …
insidious disability worsening that is independent from clinically apparent relapses and is …
The potential of serum neurofilament as biomarker for multiple sclerosis
Multiple sclerosis is a highly heterogeneous disease, and the detection of neuroaxonal
damage as well as its quantification is a critical step for patients. Blood-based serum …
damage as well as its quantification is a critical step for patients. Blood-based serum …
Association of early progression independent of relapse activity with long-term disability after a first demyelinating event in multiple sclerosis
C Tur, P Carbonell-Mirabent, Á Cobo-Calvo… - JAMA …, 2023 - jamanetwork.com
Importance Progression independent of relapse activity (PIRA) is the main event responsible
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
for irreversible disability accumulation in relapsing multiple sclerosis (MS). Objective To …
Advances in neurodegenerative diseases
J Van Schependom, M D'haeseleer - Journal of clinical medicine, 2023 - mdpi.com
Neurological disorders are the leading cause of physical and cognitive disability across the
globe, currently affecting approximately 15% of the worldwide population [1]. Absolute …
globe, currently affecting approximately 15% of the worldwide population [1]. Absolute …
Association of brain atrophy with disease progression independent of relapse activity in patients with relapsing multiple sclerosis
Importance The mechanisms driving neurodegeneration and brain atrophy in relapsing
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …
multiple sclerosis (RMS) are not completely understood. Objective To determine whether …