Biocatalytic drugs, including natural and artificial enzymes that can accelerate biochemical
reactions, are promising tools to address redox imbalances, metabolic disorders and …

Remarkable progress has been made in the development of new therapies for cancer,
dramatically changing the landscape of treatment approaches for several malignancies and …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

The cardiovascular system is affected broadly by severe acute respiratory syndrome
coronavirus 2 infection. Both direct viral infection and indirect injury resulting from …

Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …

A close and intriguing relationship has been suggested between heart failure (HF) and
coronavirus disease 2019 (COVID-19). First, COVID-19 pandemic represented a global …

Clinical application of doxorubicin (DOX), an anthracycline antibiotic with potent anti-tumor
effects, is limited because of its cardiotoxicity. However, its pathogenesis is still not entirely …

Allicin (diallylthiosulfinate) is a defense molecule produced by cellular contents of garlic
(Allium sativum L.). On tissue damage, the non-proteinogenic amino acid alliin (S …

Doxorubicin is a commonly used chemotherapeutic agent for the treatment of a range of
cancers, but despite its success in improving cancer survival rates, doxorubicin is cardiotoxic …

Cardiovascular diseases (CVDs) are considered as the major reason for mortality and
morbidity worldwide. Substantial evidence suggests that increased oxidative stress plays a …