Endosomes are central protein-sorting stations at the crossroads of numerous membrane
trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and …

Sorting nexins (SNXs) are a family of membrane-binding proteins known to play a critical
role in regulating endocytic pathway sorting and endosomal membrane trafficking. Among …

The multisubunit HOPS tethering complex is a well-established regulator of lysosome fusion
with late endosomes and autophagosomes. However, the role of the HOPS complex in other …

Introduction Cytomegaloviruses (CMVs) extensively reorganize the membrane system of the
cell and establish a new structure as large as the cell nucleus called the assembly …

Chlamydia trachomatis, a leading cause of bacterial sexually transmitted infections, creates
a specialized intracellular replicative niche by translocation and insertion of a diverse array …

The Retriever complex recycles a wide range of transmembrane proteins from endosomes
to the plasma membrane. The cargo adapter protein SNX17 has been implicated in …

In eukaryotes, the spatiotemporal control of endolysosomal organelles is central to the
maintenance of homeostasis. By providing an interface between the cytoplasm and external …

The ADP-ribosylation factors (ARFs) and ARF-like (ARL) GTPases serve as essential
molecular switches governing a wide array of cellular processes. In this study, we used …

Abstract Sorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane
recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse …

Backgrounds Pathological cardiac hypertrophy is considered one of the independent risk
factors for heart failure, with a rather complex pathogenic machinery. Sorting nexins (SNXs) …