Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry
Nitrogen containing heterocycles are of immense research interest because they are often
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …
found as naturally occurring bioactive compounds. The prominence of N-heterocycles …
Pyrazoline hybrids as promising anticancer agents: An up-to-date overview
Pyrazolines are five-membered heterocycles possessing two adjacent nitrogens. They have
attracted significant attention from organic and medicinal chemists due to their potent …
attracted significant attention from organic and medicinal chemists due to their potent …
Synthesis of new pyridine-thiazolidin-4-one and pyridine-pyrazole-thiazolidin-4-one conjugates: Molecular modelling and docking as antimicrobial agents
A series of new functionalized pyridine-thiazolidin-4-one and pyridine-pyrazole-thiazolidin-4-
one conjugates was synthesized. The DFT/B3LYP approach revealed that the synthesized …
one conjugates was synthesized. The DFT/B3LYP approach revealed that the synthesized …
Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
Microbial Multidrug Resistance (MDR) is an emerging global crisis. Derivatization of natural
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
or synthetic scaffolds is among the most reliable strategies to search for and obtain novel …
Synthesis and evaluation of 1, 3, 5-triaryl-2-pyrazoline derivatives as potent dual inhibitors of urease and α-glucosidase together with their cytotoxic, molecular …
In the present work, a concise library of 1, 3, 5-triaryl-2-pyrazolines (2a–2q) was designed
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
and synthesized by employing a multistep strategy, and the newly synthesized compounds …
Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for …
Abstract A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4, 5-dihydropyrazol-1-
yl) benzenesulfonamides 1–8 were designed since sulfonamide and pyrazoline …
yl) benzenesulfonamides 1–8 were designed since sulfonamide and pyrazoline …
Desymmetrization of 1, 3-diones by catalytic enantioselective condensation with hydrazine
B Yang, J Dai, Y Luo, KK Lau, Y Lan… - Journal of the …, 2021 - ACS Publications
We present herein an unprecedented desymmetrization of meso 1, 3-diones by
enantioselective intermolecular condensation. Under the catalysis by a chiral phosphoric …
enantioselective intermolecular condensation. Under the catalysis by a chiral phosphoric …
Synthesis, characterization, molecular docking and biological activities of novel pyrazoline derivatives
In this study, synthesis of ethyl 2‐((4‐bromophenyl) diazenyl)‐3‐oxo‐phenylpropanoate 1
was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as …
was carried out and a series of new 3H‐pyrazol‐3‐ones (P1–7) were synthesized from 1 as …
One-pot and two-pot synthesis of chalcone based mono and bis-pyrazolines
Pyrazoline is an important heterocyclic compound in organic and pharmaceutical industry.
The pyrazoline-based compounds are intensively used in medicines and agricultural …
The pyrazoline-based compounds are intensively used in medicines and agricultural …
N-, O- and S-Heterocycles Synthesis in Deep Eutectic Solvents
The synthesis of heterocycles is a fundamental area of organic chemistry that offers
enormous potential for the discovery of new products with important applications in our daily …
enormous potential for the discovery of new products with important applications in our daily …