Status and prospects of genome‐wide association studies in plants
Genome‐wide association studies (GWAS) have developed into a powerful and ubiquitous
tool for the investigation of complex traits. In large part, this was fueled by advances in …
tool for the investigation of complex traits. In large part, this was fueled by advances in …
The post-GWAS era: from association to function
During the past 12 years, genome-wide association studies (GWASs) have uncovered
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
thousands of genetic variants that influence risk for complex human traits and diseases. Yet …
Causal relationship between gut microbiota and cancers: a two-sample Mendelian randomisation study
Y Long, L Tang, Y Zhou, S Zhao, H Zhu - BMC medicine, 2023 - Springer
Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …
microbiota is associated with cancer. However, the causal association between gut …
A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
Genomic diversifications of five Gossypium allopolyploid species and their impact on cotton improvement
Polyploidy is an evolutionary innovation for many animals and all flowering plants, but its
impact on selection and domestication remains elusive. Here we analyze genome evolution …
impact on selection and domestication remains elusive. Here we analyze genome evolution …
Update on NAFLD genetics: from new variants to the clinic
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of liver diseases in high-
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
income countries and the burden of NAFLD is increasing at an alarming rate. The risk of …
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
One of the justifiable criticisms of human genetic studies is the underrepresentation of
participants from diverse populations. Lack of inclusion must be addressed at-scale to …
participants from diverse populations. Lack of inclusion must be addressed at-scale to …
LDBlockShow: a fast and convenient tool for visualizing linkage disequilibrium and haplotype blocks based on variant call format files
The triangular correlation heatmap aiming to visualize the linkage disequilibrium (LD)
pattern and haplotype block structure of SNPs is ubiquitous component of population-based …
pattern and haplotype block structure of SNPs is ubiquitous component of population-based …
Second-generation PLINK: rising to the challenge of larger and richer datasets
Background PLINK 1 is a widely used open-source C/C++ toolset for genome-wide
association studies (GWAS) and research in population genetics. However, the steady …
association studies (GWAS) and research in population genetics. However, the steady …
Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing
Z Xue, K Huang, C Cai, L Cai, C Jiang, Y Feng, Z Liu… - Nature, 2013 - nature.com
Mammalian pre-implantation development is a complex process involving dramatic changes
in the transcriptional architecture,,,. We report here a comprehensive analysis of …
in the transcriptional architecture,,,. We report here a comprehensive analysis of …