Exploring the impact of physicochemical properties of liposomal formulations on their in vivo fate
Liposomes, vesicles composed of a phospholipid bilayer, are considered a remarkably
advanced drug delivery system due to their unique properties, including their …
advanced drug delivery system due to their unique properties, including their …
Engineering macromolecular nanocarriers for local delivery of gaseous signaling molecules
In addition to being notorious air pollutants, nitric oxide (NO), carbon monoxide (CO), and
hydrogen sulfide (H 2 S) have also been known as endogenous gaseous signaling …
hydrogen sulfide (H 2 S) have also been known as endogenous gaseous signaling …
ROS-responsive liposomes as an inhaled drug delivery nanoplatform for idiopathic pulmonary fibrosis treatment via Nrf2 signaling
J Liu, Z Wu, Y Liu, Z Zhan, L Yang, C Wang… - Journal of …, 2022 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with
pathophysiological characteristics of transforming growth factor-β (TGF-β), and reactive …
pathophysiological characteristics of transforming growth factor-β (TGF-β), and reactive …
Elucidating inhaled liposome surface charge on its interaction with biological barriers in the lung
J Zhao, L Qin, R Song, J Su, Y Yuan, X Zhang… - European journal of …, 2022 - Elsevier
Liposome is the promising nanocarrier for pulmonary drug delivery and surface charge is its
basic property. However, there is a lack of knowledge about relationship between the …
basic property. However, there is a lack of knowledge about relationship between the …
Nanomedicine-mediated therapeutic approaches for pulmonary arterial hypertension
Highlights•Nanomedicine has emerged as a field with great opportunities to improve
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …
treatment strategies.•Pulmonary arterial hypertension (PAH) is a serious and incurable …
[HTML][HTML] Nanoparticle endothelial delivery of PGC-1α attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling
Pulmonary hypertension (PH) induced by chronic hypoxia is characterized by thickening of
pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure …
pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure …
Exploring the influence of inhaled liposome membrane fluidity on its interaction with pulmonary physiological barriers
J Zhao, J Su, L Qin, X Zhang, S Mao - Biomaterials Science, 2020 - pubs.rsc.org
Liposomes are promising vectors for pulmonary drug delivery, and have been used in
marketed inhalation products. Membrane fluidity is an important property of liposomes …
marketed inhalation products. Membrane fluidity is an important property of liposomes …
Newer approaches and novel drugs for inhalational therapy for pulmonary arterial hypertension
Introduction: Pulmonary arterial hypertension (PAH) is a progressive disease characterized
by remodeling of small pulmonary arteries leading to increased pulmonary arterial pressure …
by remodeling of small pulmonary arteries leading to increased pulmonary arterial pressure …
Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions
Liposomes, as a colloidal drug delivery system dating back to the 1960s, remain a focal
point of extensive research and stand as a highly efficient drug delivery method. The …
point of extensive research and stand as a highly efficient drug delivery method. The …
Fasudil and DETA NONOate, loaded in a peptide-modified liposomal carrier, slow PAH progression upon pulmonary delivery
We investigated the feasibility of a combination therapy comprising fasudil, a Rho-kinase
inhibitor, and DETA NONOate (diethylenetriamine NONOate, DN), a long-acting nitric oxide …
inhibitor, and DETA NONOate (diethylenetriamine NONOate, DN), a long-acting nitric oxide …